ID G3TS17_LOXAF Unreviewed; 592 AA.
AC G3TS17;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=HMG-box containing 4 {ECO:0000313|Ensembl:ENSLAFP00000018375.1};
GN Name=HMGXB4 {ECO:0000313|Ensembl:ENSLAFP00000018375.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018375.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018375.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018375.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018375.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018375.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3TS17; -.
DR STRING; 9785.ENSLAFP00000018375; -.
DR Ensembl; ENSLAFT00000034679.1; ENSLAFP00000018375.1; ENSLAFG00000021824.2.
DR eggNOG; ENOG502QSH9; Eukaryota.
DR GeneTree; ENSGT00390000012436; -.
DR HOGENOM; CLU_032486_0_0_1; -.
DR InParanoid; G3TS17; -.
DR OMA; MKPLFVN; -.
DR TreeFam; TF106404; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016589; C:NURF complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR CDD; cd21982; HMG-box_HMGXB4; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR025228; DUF4171.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR042477; HMGXB4.
DR InterPro; IPR048016; HMGXB4_HMG-box.
DR PANTHER; PTHR46584; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46584:SF1; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13775; DUF4171; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 398..466
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 398..466
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 62..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..339
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..372
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 65154 MW; 2428BC6A1702DEE5 CRC64;
MAYDDSMKKE DCFDGDHSFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ VRNSSKKKLK
ESELYFLGTD THKKKRKHSS DDYCFGDIAS LESSQKKKKK SSPQSADTAM DLLKAITSPL
APGSKPSKKT GEKSSSSSSH SESKKEHHKK KVSGSSGELS LEDCGSHKSK KMKPLYVNTE
TLTLREPDGL KMKLILSPKE KGSSSVDEES FQYPSPQATV KKSSKKSARD EQGALFLGHE
LQSFLKSARK KHKSSSDPHS SPGPEGSDAP QFPEPHNANL DLSEIEPILV ESDSSSGGEL
EAGELVIDDS YREIKKKKKS KKSKKKKDKE KHKEKRHSKS KRTVGEVTMT PAPPPSIPYP
GAAAPPPPLP SLHTDGHSEK KKKREDKDRE RERGEKPKKK NMSAYQVFCK EYRVTIVADH
PGIDFGELSK KLAEVWKQLP EKDKLIWKQK AQYLQHKQNK AEATTVKRKA SSSEGSVKVK
ASSTGVLSPQ KKSPPSTILL PSSPAKAPET EPIDVAAHLQ LLGESLSLIG HRLQETEGMV
AVSGSLSVLL DSIICALGPL ACLTTQLPEL NGCPKQVLSN TLDNIAYIMP GL
//
