ID G3TSJ5_LOXAF Unreviewed; 1058 AA.
AC G3TSJ5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Glutamate receptor interacting protein 2 {ECO:0000313|Ensembl:ENSLAFP00000018553.1};
GN Name=GRIP2 {ECO:0000313|Ensembl:ENSLAFP00000018553.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018553.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018553.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018553.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018553.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018553.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TSJ5; -.
DR STRING; 9785.ENSLAFP00000018553; -.
DR Ensembl; ENSLAFT00000028540.1; ENSLAFP00000018553.1; ENSLAFG00000032264.1.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000155615; -.
DR HOGENOM; CLU_004313_0_0_1; -.
DR InParanoid; G3TSJ5; -.
DR OMA; QLYPGYE; -.
DR TreeFam; TF326909; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0098887; P:neurotransmitter receptor transport, endosome to postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0099003; P:vesicle-mediated transport in synapse; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 7.
DR Gene3D; 2.30.42.10; -; 7.
DR InterPro; IPR043545; GRIP1/2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR46227:SF4; GLUTAMATE RECEPTOR-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR46227; GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP; 1.
DR Pfam; PF00595; PDZ; 6.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 7.
DR SUPFAM; SSF50156; PDZ domain-like; 7.
DR PROSITE; PS50106; PDZ; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 36..119
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 136..222
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 236..320
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 445..520
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 546..633
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 648..730
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 974..1056
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 391..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 114248 MW; 9C39650F24D8DFFD CRC64;
DDAPYSKGGK DAGGADVALV CRRQSIPAEE FRGVTMVELI KKEGSTLGLT ISGGTDKDGK
PRVSNLRPGG LAARSDLLNV GDYIRSVNGI HLTRLRHDEI ITLLKNVGER VVLEVEYELP
PPASENNPGI ISKTVDVSLY KEGNSFGFVI RGGAHEDGHK SRPLVLTYVR PGGPADREGS
LKAGDRLLSV DGVPLHGASH AAALATLRQC SHEALFQVEY DVATPDTVAN ASGPLMVEIS
KTPGSTLGIS LTTCSHRNKP VITIDRIKPA SVVDRSGALH AGDHILSIDG TSTEHCSLLE
ATKLLAGVSE KVRLEILPAP QSRRPLKPSE AVKVQRSEQP YRWDPCMPTC HSPRPPGHCR
TPTWAMPANQ DHSRSLSSTP FSSPTMNHAF SCANPSTLPR GTQPMSPRTT MGRRRQRRRE
HKSSLSLASS TVGPGGQIVH TETTEVVLCG DPLSGFGLQL QGGIFATETL SSPPLVRFIE
PDSPAERCGL LQVGDRVLSI NGIATEDGTM EEANQLLRDA ALAHKVVLEI EFDVAESVIP
SSGTFHVKLP KRRGVELGIT ISSPATASRK RGEPLIISDI KKGSVAHRTG TLEPGDKLLA
IDNIRLDNCP MEDAVQILRQ CEDLVKLKVR KDEDNSDEQE TTGAISYTVE LKRYGGPLGI
TISGTEEPFD PIIISGLTKR GLAERTGAIH VGDRILAINS VSLKGRPLSE AIHLLQVAGE
TVTLKIKKQL DRFACATSPK TQPCAGSLSE ASDADEDPPE ALKGGLLASR FSPAVPSVDS
AVESWDSSTT EGGFVGTGSY TSQAAARGVA PQEWRPGRLR SSPPPTEPRR RSYTPAPADE
SFHWEPPTRS VFLRYSPVPG PASKEGFWHV FGEALEDLES CGQSELLREL EISSVDSKLP
FTLDLSKPVS NPCLAPGYYF IPKDSMFLYY SCTVQSVALE SRPGPGPWRR SREVCPPPEE
MQELLLPTPL EMHKVTLHKD PMRNDFGFSV SDGLLEKGVY VHTVRPDGPA QRGGLRPFDR
VLQVNHVRTR DFDCCLAVPL LAEAGDILEL VVSRNPLA
//
