ID G3TTF6_LOXAF Unreviewed; 873 AA.
AC G3TTF6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=FCH and mu domain containing endocytic adaptor 1 {ECO:0000313|Ensembl:ENSLAFP00000018864.1};
GN Name=FCHO1 {ECO:0000313|Ensembl:ENSLAFP00000018864.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018864.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018864.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018864.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018864.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018864.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR AlphaFoldDB; G3TTF6; -.
DR Ensembl; ENSLAFT00000032330.1; ENSLAFP00000018864.1; ENSLAFG00000004690.3.
DR GeneTree; ENSGT00940000160489; -.
DR HOGENOM; CLU_007107_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF6; F-BAR DOMAIN ONLY PROTEIN 1; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 1..248
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 609..872
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 150..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 95255 MW; 66AA59F2F3856550 CRC64;
MSYFGEHFWG EKNHGFEVLY HSVKQGPIAT KELADFIRER ATIEETYSKA MAKLSKLASN
GTPVGTFAPL WEVFRVSSDK LALCHLELTR KLQDLIKDVL RCGEEQLKMH KKCKEEVVGT
LDAVQVFGGV NQLLPKSREN YLNRCMDQER LRRESTSQKE MDKAEAKTKK AAESLRRSVE
KYNSARADFE QKMLDSALRF QAMEEAHLKH MKALLGSYAH SVEDTHVQIG QVHEEFKQNI
ENVSVEMLLR KFAESKGTGQ EKPGPLDFET YSAAALQEAM KRLRGAKAFR LPGLSRRDRE
PPAAVDSMEP DSGTCPEVDE EGFTVRPDVT QNNIAHTVEP SRFSSSDSDF DDEEPRKFYV
HIKRSPEAAV AQLRATAGSL ILPPGPGGTM KRHSSRDAAG KPQRPRSAPR ASSCAEKPQS
EEQCSKSLFG PPLESAFDHE DFTGSSSLGF TSSPSPFSSS SPENVEDSGL DSPSHAAPGP
SPDSWVPRPG TPQSPSCRRA LTPECRGAQA PPPDSPQPLT VSPGPWGLEA EAGGGVEGTQ
TREEGLAAPP RRPRSRKVSC PLTRSNGDLS RSLSPSPLGT APERSSFSTQ TGLGVSRGPS
PVVLGSQDAL PVATAFTEYV HAYFRGHSTS CLARVTGELT MTFPAGIMRV FSGTPPPPVL
SFRLVHTASI EHFQPNSDLL FSDPSQSDPE AKDFWLNMAA LTEALQRQAE QNPAASYYNV
VLLRYQFSRP SAQSVPLQLS AQWQCSTTLT QVSVEYSYRP GATAVPTPLT NVQIVLPVGE
PVTNVHLQPA ATWNLEEKRV LWRLPDVSEA GGSGHLSASW EPCSGPSTPS PVAAQFTSEG
TTLSGVDLEL VGSGYRMSLV KRRFATGMYL VSC
//
