ID G3TTM8_LOXAF Unreviewed; 960 AA.
AC G3TTM8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Formin like 2 {ECO:0000313|Ensembl:ENSLAFP00000018936.1};
GN Name=FMNL2 {ECO:0000313|Ensembl:ENSLAFP00000018936.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000018936.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000018936.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018936.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000018936.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000018936.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR AlphaFoldDB; G3TTM8; -.
DR Ensembl; ENSLAFT00000032005.1; ENSLAFP00000018936.1; ENSLAFG00000001605.3.
DR GeneTree; ENSGT00940000155515; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF5; FORMIN-LIKE PROTEIN 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 1..403
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 490..881
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 913..950
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 454..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 315..412
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 855..886
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 454..473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 109950 MW; A55C1E8889A1FD73 CRC64;
QERFQVKNPP HTYIQKLKGY LDPAVTRKKF RRRVQESTQV LRELEISLRT NHIGWVREFL
NEENKGLDVL VEYLSFAQYA VTFDFESVES TVESSMDKSK PWSRSIEDLH RGSNLPSPVG
SSVSRSGRHS ALRYNTLPSR RTLKNSRLVS KKDDVHVCIM CLRAIMNYQY GFNMVMSHPH
AVNEIALSLN NKNPRTKALV LELLAAVCLV RGGHEIILSA FDNFKEVCGE KQRFEKLMEH
FRNEDNNIDF MVASMQFINI VVHSVEDMNF RVHLQYEFTK LGLDEYLDKL KHTESDKLQV
QIQAYLDNVF DVGALLEDAE TKNAALERVE ELEENISHLS EKLQDTENEA MSKIVELEKQ
LMQRNKELDV VREIYKDANT QVHTLRKMVK EKEEAIQRQS TLEKKIHELE KQGTIKIQKK
GDGEIAILPV VASGTLPVGS EVAVAPLPGP AAETVPAPPL PPPPPPSAPP LPGTSSPTVV
FNSGLAAVKI KKPIKTKFRM PVFNWVALKP NQINGTVFNE IDDERILEDL NVDEFEEIFK
TKAQGPAIDL SSSKQKITQK GSNKVTLLEA NRAKNLAITL RKAGKTADEI CKAIHVFDLK
TLPVDFVECL MRFLPTENEV KVLRLYERER KPLENLSDED RFMMQFSKIE RLMQKMTIMA
FIGNFAESIQ MLTPQLHAVI AASVSIKSSQ KLKKILEIIL ALGNYMNSSK RGAVYGFKLQ
SLDLLLDTKS TDRKQTLLHY ISNVVKEKYH QVSLFYNELH YVEKAAAVSL ENVLLDVKEL
QRGMDLTKRE YTMHDHNTLL KDFILNNEGK LKKLQDDAKI AQDAFDDVVK YFGENPKTTP
PSVFFPVFVR FVKAYKQAEE ENELRKKQEQ ALMEKLLEQE ALMEQQDPKS PSHKSKRQQQ
ELIAELRRRQ VKDNRHVYEG KDGAIEDIIT VLKTVPFTAR TAKRGSRFFC EPVLTEEYHY
//
