ID   G3TU77_LOXAF            Unreviewed;       435 AA.
AC   G3TU77;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083, ECO:0000256|PIRNR:PIRNR007858};
GN   Name=ORC4 {ECO:0000313|Ensembl:ENSLAFP00000019135.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019135.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000019135.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019135.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000019135.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019135.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. {ECO:0000256|PIRNR:PIRNR007858}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR007858}.
CC   -!- SIMILARITY: Belongs to the ORC4 family. {ECO:0000256|ARBA:ARBA00005334,
CC       ECO:0000256|PIRNR:PIRNR007858}.
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DR   AlphaFoldDB; G3TU77; -.
DR   STRING; 9785.ENSLAFP00000019135; -.
DR   Ensembl; ENSLAFT00000027793.1; ENSLAFP00000019135.1; ENSLAFG00000002631.3.
DR   eggNOG; KOG2228; Eukaryota.
DR   GeneTree; ENSGT00390000016542; -.
DR   InParanoid; G3TU77; -.
DR   OMA; ETKFRHH; -.
DR   TreeFam; TF101094; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:Ensembl.
DR   GO; GO:0000166; F:nucleotide binding; IEA:Ensembl.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR   GO; GO:0040038; P:polar body extrusion after meiotic divisions; IEA:Ensembl.
DR   GO; GO:0051258; P:protein polymerization; IEA:Ensembl.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR016527; ORC4.
DR   InterPro; IPR032705; ORC4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR   PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF14629; ORC4_C; 1.
DR   PIRSF; PIRSF007858; ORC4; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|PIRNR:PIRNR007858};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR007858};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007858};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          60..201
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   435 AA;  50281 MW;  D6F37923B4A5132E CRC64;
     MSSRKSKSNN LIHAECLSQQ VQRILRERFC HQSSHSNLFG VQVQYKHLIE LLKRTAIHGE
     SNSVLIIGPR GSGKTMLVNH ALKELMQIEE VNENVLQVHL NGLLQINDKI ALKEITRQLN
     LENVVDDKVF GSFAENLSFL LEALKKVSKS SSCPVIFIDE FDLFAHHNQT LLYTLFDISQ
     AAQTPVAVIG LTCRLDILEL LEKRVKSRFS HRQIHLMNSF GFPQYLKIFK EQLSLPAEFP
     DKLFAEKWNE NIQCLSEDRS IREVLQKHFN VSKNLRSLHM LLMLALNRVT SSHPFMTAAD
     LMEASQLCSM DSKANIVHGL SVLEICLIIA MKHLNDIYEE EPFNFQMVYN EFQKFVQRKA
     HSIYNFEKPV VMKAFEHLQQ LELIKPMERT SLNAQKEYQL MKLLLDNTQI MNALQKYPNC
     PTDVRQWATS SLSWL
//