ID   G3TUR1_LOXAF            Unreviewed;       674 AA.
AC   G3TUR1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO3 {ECO:0000313|Ensembl:ENSLAFP00000019319.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019319.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000019319.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019319.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000019319.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019319.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; G3TUR1; -.
DR   Ensembl; ENSLAFT00000029540.1; ENSLAFP00000019319.1; ENSLAFG00000002255.3.
DR   GeneTree; ENSGT00940000156257; -.
DR   HOGENOM; CLU_006685_3_0_1; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        106..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        183..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        258..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        302..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        353..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        470..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        520..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        615..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          2..92
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          95..658
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   674 AA;  79235 MW;  39AB4656F3789BC6 CRC64;
     LNSFIINNKD TFFSNATRSR IVYHVLQRTK YENGISKVGI CKLINNGAYE AAFPPHEERI
     LRNYQNISNK NNRHLLYERW ARWGMWYKHQ PLDLIRRYFG EKIGLYFAWL GWYTGMLIPA
     AIVGLCVFFY GLFTMNGSQV SQEICAAAEV FMCPLCDKNC SLQRLNDSCI YAKVTYLFDN
     GGTVFFAIFM AIWATVFLEF WKRRRSILTY AWDLIEWEEE EETLRPQFEA KYYTVERVNP
     ITGKPEPHQP FSDKITRLLI SVSGIFFMIS LVITAVFAVV VYRLVVMEQF ASFKWSFIKQ
     HWQFATSAAG VCINFVIIMM LNVAYEKIAY LLTNLEYPRT ESEWENSFAL KMFLFQFVNL
     NSSIFYIAFF LGRFVGHPGN YNKLFNRWRL EECHPSGCLI DLCLQMGVIM FLKQIWNNFM
     ELGYPLIQNW WSRHKIKRGI QDASLPQWEN DWNLQPMNIH GLMDEYLEMV LQFGFTTIFV
     AAFPLAPLLA LLNNIIEIRL DAYKFVTQWR RPLPARATDI GIWYGILEGI GILAVITNAF
     VIAITSDYIP RLVYEYKYGP CADRFTYICL KGYVNNSLSF FDLSELGIGK SGYCRYRDYR
     GPPWSSKPYE FTLQYWHILA ARLAFIIVFE HLVFGIKSFI AFLIPDVPQD LYDRIRREKY
     LVQEMMYEAE LEHL
//