ID   G3TUY9_LOXAF            Unreviewed;       572 AA.
AC   G3TUY9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Solute carrier family 23 member 1 {ECO:0008006|Google:ProtNLM};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019397.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000019397.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019397.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000019397.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019397.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   AlphaFoldDB; G3TUY9; -.
DR   STRING; 9785.ENSLAFP00000019397; -.
DR   Ensembl; ENSLAFT00000029654.1; ENSLAFP00000019397.1; ENSLAFG00000029658.1.
DR   eggNOG; KOG1292; Eukaryota.
DR   GeneTree; ENSGT00950000182953; -.
DR   HOGENOM; CLU_017959_5_4_1; -.
DR   InParanoid; G3TUY9; -.
DR   OMA; GLGFDWN; -.
DR   TreeFam; TF313272; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   PANTHER; PTHR11119:SF22; SOLUTE CARRIER FAMILY 23 MEMBER 4; 1.
DR   PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        148..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        281..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        397..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   572 AA;  61681 MW;  A5C98E0E78B2FD1B CRC64;
     LAYGILDTPP WHLCIFLGIQ HFLTALGGLV AVPLILAKDL CLQHDPLTQS YLISTIFFVS
     GICTLLQVFL GVRLPILQGG TFAFLAPSLA MLSLPAWRCP PSEEGVGKVP LPFRRNHVWH
     PQIRELQGTI MVASCVQMLV GFSGLIGFLM RFIGPLTIAP TISLVALPLF DSAGNDAGNH
     WGIAAMTIFL IVLFSQYLKN ITVPVLVYGQ KKKFHTSKFH LFQVFPVLLA LCISWLTCFV
     LTVTDALPSA PAAYGHWART DTKGSVLSQA PWFRVPYPGQ WGLPTISLAG VCGIIAGVIS
     SMVESVGDYY ACARLVGAPT PPRHAINRGI GIEGLGCLLA GAWGTGNGTT SYSENVGVLG
     ITQVGSRMVI VAAGCVLLLM GVFGKIGAAF ATIPTPVIGG MFLVMFGVIT AVGISNLQYV
     DMNSSRNLFV FGFSIYCGLA IPNWVNKNPE RLQTGILQLD QVIQVLLTTG MFVGGSLGFL
     LDNTIPGSVE ERGLLAWNQS QEESEATSEA SEIYGLPCGI GTKFYTSSCS WCLPFWPQLE
     GVRKREVEVS QLTLCSLDVP GYRRKGDQET RM
//