ID G3TVI1_LOXAF Unreviewed; 800 AA.
AC G3TVI1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000019589.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000019589.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019589.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000019589.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000019589.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3TVI1; -.
DR Ensembl; ENSLAFT00000001302.3; ENSLAFP00000019589.1; ENSLAFG00000001302.3.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000163201; -.
DR InParanoid; G3TVI1; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF333; PROTOCADHERIN BETA-12; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..800
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003455840"
FT TRANSMEM 688..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 356..451
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 452..561
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 576..676
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 800 AA; 87616 MW; 0C2F98C4477048D0 CRC64;
MENGGPGTLR TRQVLLLFVL LGISQAVSES GRFSVAEEMQ SGSFIGNLAK DLGLEVGELS
SRGAQIVSKD NKQHLQLDLN TGDLLLRETL DREELCGSTQ QCVLHFQVLM KNPLQFFRIE
LQVRDINDHS PVFLEKEMRL EIPENSPVGA VFLLESAKDL DVGINTIKNY TISPNSNFHV
KIRVNPDNRK YPELVLDKAL DYEGQPELSF ILTALDGGSP PRSGTALVRV VVVDINDNAP
EFEQPFYDVK IPENSILGSP VVTVSAWDLD SGTNGEISYT LSHASEDICK TFEINQKSGE
VILTALLDFE TTESYSIIIQ ATDGGGLFGK STVRIQVMDV NDNAPEVTVS SVISPIPENS
PETVVVVFSI LDRDSGDNGR MICSIPEDLP FTLKPSVENY YTLETEGTLD REIRAEYNIT
ITVADLGTPR LKTQHNIILL VSDVNDNAPI FSQTSYTLFV RENNSPALHM GSVSATDRDS
GSNAQVTYSL LPPQDPHLPL ASLVSINVDN GHLFALRSLD YEALRAFEFC VGATDAGSPA
LSSEALVRVE VMDENDNSPF VLYPLQNDSA PCTELVPRAA EAGYLVTKVV AMDSDSGQNA
WLSYQLLKAT EPGLFSVWAH NGEVRTARLL SERDGVKHRL IVLVKDNGEP PRSTSVTLHV
LLVDGFSQPY LPLPEVALDE AQADSLTVYL VIALTSVSSL FLFSLLSFIA VWLCRRNRAA
SVDCRSVPEG HFPSHLVDVS GTGTLSQRYL YEAFLTGGSG TNEFKFLKPI IPNFPPQGPG
KEIEENPSFL NSFGFSIHCN
//
