ID G3TX27_LOXAF Unreviewed; 708 AA.
AC G3TX27;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 08-NOV-2023, entry version 61.
DE SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSLAFP00000020135.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020135.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020135.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020135.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020135.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020135.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; G3TX27; -.
DR Ensembl; ENSLAFT00000034417.1; ENSLAFP00000020135.1; ENSLAFG00000028729.1.
DR GeneTree; ENSGT01070000253775; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF113; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 2.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 111..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 298..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 334..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 585..691
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 478..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 76936 MW; 450966B1553B25E6 CRC64;
VFLSCHPLDR GTRRHCCSAM QTMELRRRDY HVERTLLNQE QLEELGHWGS APTRQWRSWF
QCSYARARAL LFQYLPVLAW LPRYPVRDWL LGDLLSGLSV AIMQLPQGLA YALLAGLPPV
FGLYSSFYPV FIYFLFGTSR HISVGTFAIM SVMVGSVTES LAPDEDFLQT PNTTVNEAAR
DAARVQLAST LSGRRARDVI SLPCGQLSVY EPLLPNPLFS SVSLLIHRVT YPFPLQHLPP
LSLPCPSLDP ALSPQLIGAT GISYGVGLKH RFGVDVVGSI PAGLVPPVPP SPELFAKLVG
NAFAIAVVGF AIAISLGKIF ALRHGYRVDS NQELVALGLS NLIGGIFQCF HISCSMSRSL
RRAPVGNPHV GCGVCLHLCI HTRLCQSTAH PLHSRTLAHL LLTPAHPLSQ PLLPLIRMSR
GFRSDVHSTY SHSLRILVLK LDVSWTFAIM SVMVGSVTES LAPDEDFLQT PNTTVNEAAR
DARPGAAGLH RKGKKVWPPG KAGRAKRLEA NWQEAASPKK TGQGTPFHPS DLPELLTSCL
IDPTQLSPAS AASSRGTSFS ISVNTGLGDT DINNVEDSKV KASTEDKLDG TVASDPEGAK
APDVSTLKAL GLPQPDFHSL ILDLSALSFV DTVCLKTLKN IFRDFREIEV EVYMAACHTP
VVAQLEVGHF FDASITKQHL FATVHDAVVF ALQHPRSGSI GPALVTQV
//