ID G3TX86_LOXAF Unreviewed; 1473 AA.
AC G3TX86;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Kinesin family member 13B {ECO:0000313|Ensembl:ENSLAFP00000020194.1};
GN Name=KIF13B {ECO:0000313|Ensembl:ENSLAFP00000020194.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020194.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020194.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020194.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020194.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020194.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSLAFT00000026461.1; ENSLAFP00000020194.1; ENSLAFG00000004531.4.
DR GeneTree; ENSGT00940000155500; -.
DR HOGENOM; CLU_001485_29_2_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22730; FHA_KIF13B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF5; -; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12473; DUF3694; 2.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 1..38
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1358..1400
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 231..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1094
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1473 AA; 164546 MW; E0EAE0DDF29C758A CRC64;
DSLGGNSKTA MVATVSPAAD NYDETLSTLR YADRAKNIVN HAVVNEDPNA RIIRDLREEV
EKLREQLTKA EAMKSPELKE RLEESEKLIQ EMTVTWEEKL RKTEEIAQER QKQLESLGIS
LQSSGIKVGD DKCFLVNLNA DPALNELLVY YLKEHTLIGS ANSQDIQLCG MGILPEHCII
DITTEGQVML TPQKNTRTFV NGSCVSSPIQ LHHGDRILWG NNHFFRLNLP KKKKKAQSED
EEHDNSMKND NSSEQLDVDG DSSSEVSSEI NFNYEYAQME VTMKALGNND PMQSILKSLE
QQHEEEKRSA LERQRLMYEH ELEQLRRRLS PEKQNYRSSM DRFPFHSPSA QQRLRQWAEE
RREATLNNSL MRLREQIVKA NLLVREASYI AEELDKRTEY KVTLQIPASS LDANKKRGSV
LSEPAIQVRR KGKGKQIWSL EKLDNRLLDM RDLYQEWKEC EEDSPVIRSY FKRADPFYDE
QENHSLIGVA NVFLESLFYD VKLQYAVPIV NQKGEVAGRL HVEVMRISGE IGERIAGGDD
AVDISFDRET QENKLVCMVK ILQATGLPQH LSHFVFCKYN FWDQQEPMIV APEVDTSSSP
VSKEPQCMVV FDHCNEFSVN ITEDFIEHLS EGALAIEVYG HKMTDPRKNP AVWDLGIIQA
KTRSLRDRWS EVTRKVEFWV QILEQNENGD YCPVEVISAK DVPTGGIFQL RQGQSRRIQV
EVKSVQESGT LPLMEECILS VGVGCIKIRP LRSPKTHETF HEERHDSTSI QDRDLERLRR
KWLNALTKRQ EYLDQQLQKL VSKHDKTEDD ADREAQLLEM RLTLTEERNA VMVPSAGSGI
PGAPAEWTPV PGMETHIPVI FLDLNADDFS SQDNLDDPEA GGWDATLTGE EEEEFFELQI
VKQHDAEVKA EASWDSAVHN CPQLSKGTPS DERVFLIVRV TVQLSHPAEM QLVLRKRICV
TVHGRQGFAQ SLLKKMSHRS SIPGCGVTFE IVSNIPEFDA QGVEEREALA RMAANVENPA
SADSEAYIEK YLRSVLAVEN LLTLDRLRQE VAVKEQLTGK GKLSRRSISS PNVNRLSGSR
QDLTPSYSLG SNKPVPRIMV QSTLLDVAVT RMEEAHQENM GISETPEVTV QIPPVVKIYD
KPAKVPSQQP LPANAQAQEV PEGPPSPLSE TSSGYFSHSV STATLSDALV TGLDAASQAA
PSSPPTPICQ VPLETDLSFP SVVSCAESHL SAPLENQTSL PSLPIQPNLE LDISKPQFPP
DLLSQSSAPT SPFRIQKVRT SELKSFTRML GGDSCSSSTE EEQLASGGSG DSNSGGQALE
KLEVVSDSEE ASEVPEWLKE GEYVTIGTNK MGIVRYIGPT DFQEGTWIGV ELDLPSGKND
GSIGGKQYFK CNPGYGLLVK PSRVRKAMGA ARRRSTGLRL QGAAASEARR SATLSGSATN
LASLTALAKA EVGAALRAER NQKSTENRKS WAS
//
