ID   G3TXK7_LOXAF            Unreviewed;       907 AA.
AC   G3TXK7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Importin 8 {ECO:0000313|Ensembl:ENSLAFP00000020315.1};
GN   Name=IPO8 {ECO:0000313|Ensembl:ENSLAFP00000020315.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020315.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000020315.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020315.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000020315.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020315.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; G3TXK7; -.
DR   Ensembl; ENSLAFT00000029754.1; ENSLAFP00000020315.1; ENSLAFG00000012885.3.
DR   GeneTree; ENSGT00940000158848; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR013713; XPO2_central.
DR   PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR   PANTHER; PTHR10997:SF26; IMPORTIN-8; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          22..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   907 AA;  105503 MW;  B0F25D4E21823000 CRC64;
     MDLNRIIQAL KGTIDPKLRI AAENELNQSY KIINFAPSLL RIIVSDHVEF PVRQAAAIYL
     KNMVTQYWPD REPPPGEAIF PFNIHENDRQ QIRENIVEGI IRSPDLVRVQ LTMCLRAIIK
     HDFPGHCVAF WFRRGWLLTH AKSCSFLSFK LMTSYCIFRI LREYFRYKKA EEREPLIAAM
     HVFLPRIQQQ IIQLLPDSSH YSVLLQKQIL KIFYALVQYA LPLQLMNHQT TTEWMEIFRT
     IIDRTVPPET LQIDEDDRPE LVWWKCKKWA LHIVARLFER IHRYGSPGTV TKEYFEFSEF
     FLKTYAVGIQ QVLLKILDQY RQKEYVAPRV LQQAFNYLNQ GVVHSVTWKQ MKPHIQNISE
     DVIFSVMCYK DEDEELWQED PYEYIRMKFD IFEDYASPTT AAQALLYTAA KKRKEVLPKM
     MAFCYQILTD PNFDPRKKDG ALHVIGSLAD ILLKKSLFKD QMELLLQNHV FPLLLSNLGY
     LRARSCWVLH AFSSLKFHNE LNLRNAVELA KKSLIEDKEM PVKVEAALAL QSLISNQIQA
     KEYMKPHVRS IMQELLHIVR ETENDDVTNV IQKMICEYSQ EVASIAVDMT QHLAEIFGKV
     LQSDEYEEVE DKTVMAMGIL HTIDTILTVV EDHKEVTQQL ENICLRIIDL VLHKHIIEFY
     EEIFSLAYSL TCHSISPQMW QLLGILYEVF QQDCFEYFTD MMPLLHNYVT IDTDTLLSNP
     KHLEILFTMC RKVLSGDAGE DAECHAAKLL EVIILQCKGR GIDQCIPLFV QLVLERLTRG
     VKTSELRTMC LQVAIAALYY NPDLLLHTLE RIQLPHNPGP ITVQFINQWM NDTDCFLGHH
     DRKMCVIGLS ILLQLQNRPP AVDAVVGQIV PSILFLFLGL KQVCASRQLL DREDHSKAEK
     ADTEENG
//