ID G3TXR9_LOXAF Unreviewed; 584 AA.
AC G3TXR9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=REC8 meiotic recombination protein {ECO:0000313|Ensembl:ENSLAFP00000020377.1};
GN Name=REC8 {ECO:0000313|Ensembl:ENSLAFP00000020377.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020377.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020377.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020377.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020377.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020377.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad21 family.
CC {ECO:0000256|ARBA:ARBA00009870}.
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DR AlphaFoldDB; G3TXR9; -.
DR STRING; 9785.ENSLAFP00000020377; -.
DR Ensembl; ENSLAFT00000032514.1; ENSLAFP00000020377.1; ENSLAFG00000031194.1.
DR eggNOG; KOG1213; Eukaryota.
DR GeneTree; ENSGT00390000011379; -.
DR HOGENOM; CLU_036680_0_0_1; -.
DR InParanoid; G3TXR9; -.
DR OMA; RVYFQQC; -.
DR TreeFam; TF338144; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0030893; C:meiotic cohesin complex; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:Ensembl.
DR CDD; cd21794; Rad21_Rec8_M_Rec8; 1.
DR Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR023093; ScpA-like_C.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585:SF27; MEIOTIC RECOMBINATION PROTEIN REC8 HOMOLOG; 1.
DR PANTHER; PTHR12585; SCC1 / RAD21 FAMILY MEMBER; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 1..112
FT /note="Rad21/Rec8-like protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04825"
FT DOMAIN 530..583
FT /note="Rad21/Rec8-like protein C-terminal eukaryotic"
FT /evidence="ECO:0000259|Pfam:PF04824"
FT REGION 310..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..330
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 66796 MW; 523396AB3C2D6575 CRC64;
MFYYPNVLQR HTGCFATIWL AATRGSRLVK REYLKVNVVK TCEEILNYVL VRVEPPQPGL
PRPRFSLYLS AQLQIGVIRV YCQQCQYLVE DIQHILERLH RAQMQIRIDM AEAELPSLLL
PSRLAMMETL EDAPDPFFGM MAVEPRLPSP FEIPQIRRLL EAVTPERVLE EIPPEVPPEL
REPERMLGIV PSPEVITLLE AEPIQILQIE GERELPEVSR RELDLLLAEE DEAILLEERR
ARLALEVSKE ELRALEGEII VPRLSPPAPA RVERAVEPLP GELLVPEELK LVPWEPTALP
IEVTPPLVLH LPAPPSPERK RPPAPPPPEG PPARRRRRQL LFWDKETQIS REKFQEQLQT
KAHCWECPMV QPPERMTMTP ADLFRTPALP GRLPPELLAF WTRCAQLPPR VLRRRPLWEL
EEEAAAEVER RIEAPSDIEV LREALEPSGP LVLPSEISLE AAEEEKPRVS LIPPEERWAW
PEAEPEALAL PVVPELPEMP VEMPLELPPE PELLSPEAVH RAVALELQAN REPDFSSLVP
PLSPRKTAAR VFYLLLVLSA QRILHVEQEK PYGRLLIQPG PRFH
//
