ID G3TY04_LOXAF Unreviewed; 119 AA.
AC G3TY04;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=DNA-binding protein inhibitor ID-3 {ECO:0000256|ARBA:ARBA00040555};
DE AltName: Full=Inhibitor of DNA binding 3 {ECO:0000256|ARBA:ARBA00043115};
DE AltName: Full=Inhibitor of differentiation 3 {ECO:0000256|ARBA:ARBA00042953};
GN Name=ID3 {ECO:0000313|Ensembl:ENSLAFP00000020462.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020462.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020462.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020462.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020462.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020462.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC transcription factors by forming heterodimers and inhibiting their DNA
CC binding and transcriptional activity. Implicated in regulating a
CC variety of cellular processes, including cellular growth, senescence,
CC differentiation, apoptosis, angiogenesis, and neoplastic
CC transformation. Involved in myogenesis by inhibiting skeletal muscle
CC and cardiac myocyte differentiation and promoting muscle precursor
CC cells proliferation. Inhibits the binding of E2A-containing protein
CC complexes to muscle creatine kinase E-box enhancer. Regulates the
CC circadian clock by repressing the transcriptional activator activity of
CC the CLOCK-BMAL1 heterodimer. {ECO:0000256|ARBA:ARBA00037443}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_003415427.1; XM_003415379.2.
DR AlphaFoldDB; G3TY04; -.
DR STRING; 9785.ENSLAFP00000020462; -.
DR Ensembl; ENSLAFT00000029739.1; ENSLAFP00000020462.1; ENSLAFG00000030385.1.
DR GeneID; 100666098; -.
DR KEGG; lav:100666098; -.
DR CTD; 3399; -.
DR eggNOG; ENOG502S53I; Eukaryota.
DR GeneTree; ENSGT00940000160504; -.
DR HOGENOM; CLU_116790_1_0_1; -.
DR InParanoid; G3TY04; -.
DR OMA; VCCLSDQ; -.
DR OrthoDB; 4207391at2759; -.
DR TreeFam; TF326217; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
DR GO; GO:1901707; F:leptomycin B binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl.
DR GO; GO:0072750; P:cellular response to leptomycin B; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR CDD; cd19693; bHLH_dnHLH_ID3; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR026052; DNA-bd_prot-inh.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11723; DNA-BINDING PROTEIN INHIBITOR; 1.
DR PANTHER; PTHR11723:SF16; DNA-BINDING PROTEIN INHIBITOR ID-3; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 28..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
SQ SEQUENCE 119 AA; 12944 MW; EB198B56B4C083D9 CRC64;
MKALSPVRGC YEAVCCLSER SLAIARGRGK GPAAEEPLSL LDDMNHCYSR LRELVPGVPR
GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLAIQ TAELTPELVI ATDKRSFCH
//