GenomeNet

Database: UniProt
Entry: G3TY04_LOXAF
LinkDB: G3TY04_LOXAF
Original site: G3TY04_LOXAF 
ID   G3TY04_LOXAF            Unreviewed;       119 AA.
AC   G3TY04;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=DNA-binding protein inhibitor ID-3 {ECO:0000256|ARBA:ARBA00040555};
DE   AltName: Full=Inhibitor of DNA binding 3 {ECO:0000256|ARBA:ARBA00043115};
DE   AltName: Full=Inhibitor of differentiation 3 {ECO:0000256|ARBA:ARBA00042953};
GN   Name=ID3 {ECO:0000313|Ensembl:ENSLAFP00000020462.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020462.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000020462.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020462.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000020462.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020462.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC       domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC       transcription factors by forming heterodimers and inhibiting their DNA
CC       binding and transcriptional activity. Implicated in regulating a
CC       variety of cellular processes, including cellular growth, senescence,
CC       differentiation, apoptosis, angiogenesis, and neoplastic
CC       transformation. Involved in myogenesis by inhibiting skeletal muscle
CC       and cardiac myocyte differentiation and promoting muscle precursor
CC       cells proliferation. Inhibits the binding of E2A-containing protein
CC       complexes to muscle creatine kinase E-box enhancer. Regulates the
CC       circadian clock by repressing the transcriptional activator activity of
CC       the CLOCK-BMAL1 heterodimer. {ECO:0000256|ARBA:ARBA00037443}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_003415427.1; XM_003415379.2.
DR   AlphaFoldDB; G3TY04; -.
DR   STRING; 9785.ENSLAFP00000020462; -.
DR   Ensembl; ENSLAFT00000029739.1; ENSLAFP00000020462.1; ENSLAFG00000030385.1.
DR   GeneID; 100666098; -.
DR   KEGG; lav:100666098; -.
DR   CTD; 3399; -.
DR   eggNOG; ENOG502S53I; Eukaryota.
DR   GeneTree; ENSGT00940000160504; -.
DR   HOGENOM; CLU_116790_1_0_1; -.
DR   InParanoid; G3TY04; -.
DR   OMA; VCCLSDQ; -.
DR   OrthoDB; 4207391at2759; -.
DR   TreeFam; TF326217; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
DR   GO; GO:1901707; F:leptomycin B binding; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl.
DR   GO; GO:0072750; P:cellular response to leptomycin B; IEA:Ensembl.
DR   GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR   GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR   GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   CDD; cd19693; bHLH_dnHLH_ID3; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR026052; DNA-bd_prot-inh.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR11723; DNA-BINDING PROTEIN INHIBITOR; 1.
DR   PANTHER; PTHR11723:SF16; DNA-BINDING PROTEIN INHIBITOR ID-3; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          28..80
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
SQ   SEQUENCE   119 AA;  12944 MW;  EB198B56B4C083D9 CRC64;
     MKALSPVRGC YEAVCCLSER SLAIARGRGK GPAAEEPLSL LDDMNHCYSR LRELVPGVPR
     GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLAIQ TAELTPELVI ATDKRSFCH
//
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