ID G3TZ27_LOXAF Unreviewed; 704 AA.
AC G3TZ27;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN Name=MPEG1 {ECO:0000313|Ensembl:ENSLAFP00000020835.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020835.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020835.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020835.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020835.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020835.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
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DR AlphaFoldDB; G3TZ27; -.
DR STRING; 9785.ENSLAFP00000020835; -.
DR Ensembl; ENSLAFT00000001227.4; ENSLAFP00000020835.1; ENSLAFG00000001227.4.
DR eggNOG; ENOG502QRKR; Eukaryota.
DR GeneTree; ENSGT00390000008048; -.
DR HOGENOM; CLU_023578_1_0_1; -.
DR InParanoid; G3TZ27; -.
DR OMA; QTHEEGY; -.
DR TreeFam; TF331165; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0061474; C:phagolysosome membrane; IEA:Ensembl.
DR GO; GO:0022829; F:wide pore channel activity; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..704
FT /note="Macrophage-expressed gene 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003456060"
FT TRANSMEM 645..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..343
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 680..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 77863 MW; 26B7A22E3491A1C1 CRC64;
MNIFRVALFF WVVAAWAKGD KPLGETDMAG FQKCKNALNL PVLEVLPGGG WDNLRNVDMG
RVMNLAYTNC RTTEDGQYII PNEIFTVPQK LSNLEMNSEI LESWVNYQSS TSYSINMELG
LFSKVNGKFS PEFQRMKTLQ VKDQSVTTRV QVRNLVYTVK INPTLELSQG FLKDLMDISN
HLENNQTRMA TYLAELLVLN YGTHVITVDA GAALIQEDHI RTSFLQDSQS SHSAVTTAGI
AFQNIINFKF EENYVSQNAL TKSYISNRTN SRVQSIGGIP FYPGITLQTW QQGIANHLVA
LDRTGLPLHF FINPEMLPGL PGPFVKKLSR TVEMAVRRYY AFNTYPGCTN FNSPNFNFQA
NTDDGSCEGK VTNFTFGGVY QECTQLSGSE AVLLCQNLEQ KNPLTGDFSC PSGYSPIHLL
SQIHEEGYNY LECQSKCTLL VFCKKVCEDV FRVAKAEFRA FWCVAHSQVP EHSGLLFGGL
FSSKSINPLT NAQSCPAGYI PLRLFESLKV CASQDYELGY KFSIPFGGFF SCAVGNPLAD
SAVRDSGAPS LKKCPGGFSQ HLALISDGCQ VSYCVKSGIF TEGSLPPVRL PPYTRPPLMS
QAATNTVMVT NTETSSSWIK DYETHQWRLG EPLEDEGGLS GGQTAGVILG VITALVAAIA
LAIYGTRKYK KRQYQAIEDE KQSLTQGPAV TEDAPHQEPE QNPV
//
