ID G3TZF8_LOXAF Unreviewed; 1045 AA.
AC G3TZF8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=RIMS binding protein 2 {ECO:0000313|Ensembl:ENSLAFP00000020966.1};
GN Name=RIMBP2 {ECO:0000313|Ensembl:ENSLAFP00000020966.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000020966.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000020966.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020966.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000020966.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000020966.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR AlphaFoldDB; G3TZF8; -.
DR Ensembl; ENSLAFT00000027422.1; ENSLAFP00000020966.1; ENSLAFG00000013819.2.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR CDD; cd00063; FN3; 3.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF18; RIMS-BINDING PROTEIN 2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 167..234
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 394..476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 490..591
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 844..912
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 948..1015
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 129..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..57
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 585..599
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..652
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 114235 MW; CFB014EA81545B44 CRC64;
MREAAERRQQ LEVEHDQALA VLTAKQQEID LLQKSKVQEL EAKCRMQSEQ FSLLSRELGK
FRQQAGAIDL LGSGPVAPLA LPSAPSKPFP PFMNGVATSI CKGQESSTGS HPVIGDYILP
LALPGEKPQP PSLKPAFLSR SRGPRCGFES DMDNEQNSNT SKQRYSGKVH LCVARYSYNP
FDGPNENPEA ELPLTAGKYL YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA
STLGSEQDQN FINHSGVGVE GGEHILALHS PTHIDPSITD NGAGTLDVNI DEIGEDIVPY
PRKITLIKQL AKSVIVGWEP PAVPPGWGTV SSYNVLVDKE MRLSLTPGSR TKALIEKLNM
AACTYRISVQ CVMSRGSSDE LQCTLLVGRD VVVAPSHLRV DNITQVSAQL SWLPTNSNYS
HVIFLNEEEF DIVKAARYKY QFFNLRPNTA YKVKVLAKPH QMPWQLPLEQ REKKEAFVEF
STLPAGPPAP PQDVTVQAGA TPGTVQVSWR PPALTPTGLS NGANVTGYGV YARGQRVAEV
IFPMADGTAV ELVRLRSLEA KAVSVRTLSA QGESVDSSVS AIPPDLLVPP APHPRTMPPV
KPSTGAGVPE TKEASPGRAP APAHGHLLEP PSPQGPGPGR RSPSPSRILP QPQGTPVPST
VAKAMAREAA QRAAESSRLE KRSVFPERGS TGYANSDEED SYGSPDIKRR GTSVDDFLKG
SELGKPPHCC HGDEDHTESS RGSDLSDIME EDEEELYSEM QLEEGGRRRP SGTSHNALKI
LGNPVSAGRA ERADHMGQRF PPGSAGPPRS RAMVVPSIDD YAGRDRLSPD FYEESETDPG
AEELPARIFV ALFDYDPLTM SPNPDAAEEE LPFKEGQIIK VYGDKDADGF YRGETCARLG
LIPCNMVSEI QADDEEMMGQ LLRQGFLPLN TPVEKIERNR RSGRRHSAPT RRMVALYDYD
PRESSPNVDV EAELTFCTGD IITVFGEIDE DGFYYGELNG HKGLVPSNFL EEVPDDVEVY
LSDVPSHYSQ DTPRRSKAKR VSKRT
//
