ID G3TZL3_LOXAF Unreviewed; 875 AA.
AC G3TZL3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LATS1 {ECO:0000313|Ensembl:ENSLAFP00000021021.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021021.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000021021.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021021.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000021021.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021021.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3TZL3; -.
DR Ensembl; ENSLAFT00000026465.1; ENSLAFP00000021021.1; ENSLAFG00000005083.3.
DR GeneTree; ENSGT00940000157684; -.
DR HOGENOM; CLU_004885_1_1_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd21778; MobB_LATS1; 1.
DR CDD; cd14397; UBA_LATS1; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR049761; LATS1-like_MobB.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF138; SERINE_THREONINE-PROTEIN KINASE LATS1; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 89..130
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 618..875
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 27..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..239
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..478
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 98211 MW; E10C88BFB9CFDCE6 CRC64;
MRPKTFPASN YTGSSRQMLQ EIRESLRNLS KPSDTAKAEH NMSKMSAEDP RQVRNPPKFG
TYHKALQEIR NSLLPFANET SSSSRSTSEV NPQMFQDLQA AGFDEDMVIQ ALQKTNNRSI
EAAIEFISKM SYQDPRREQM AAAAARPLNA NVKPGPFHRK QSWKGSKESL VPQRHVPPLG
ESVAYRSESP NSQTDVGRPL SGSGIAAFAQ AHPSNGQRVN PPPPPQEGYP PPPLNTSPMN
PPNQGQRGMS SVPVGRQPII MQSSNKYNFP PGRPGIQNGS GQSDFMIHQT VVPAGTVNRQ
PPPPYPLTPR GSAAPSSYTN GNIPQSMMVP NRNSHNMELY NINTTWPQSS SAPAQSSPNS
GHEIPTWQPN IPVRSNSFNN PLGNRTSHST NSQPSATTVT AITPAPIQQP VKSIRVLKPE
LQTALAPTHP SWIPQPIQTV QPCPFSEGTT SSMTVMPPVA EAPNYQGPPP PYPKHLLHQN
PSVPPYESIH KSSKEDQPGL PKEEEGEKSY ENVDSGDKEK KQITTSPITV RKNKKDEERR
ESRIQSYSPQ AFKFFMEQHV ENVLKSHQQR LHRKKQLENE MMRVGLSQDA QDQMRKMLCQ
KESNYIRLKR AKMDKSMFVK IKTLGIGAFG EVCLARKVDT KALYATKTLR KKDVLLRNQV
AHVKAERDIL AEADNEWVVR LYYSFQDKDN LYFVMDYIPG GDMMSLLIRL GIFPENLARF
YIAELTCAVE SVHKMGFIHR DIKPDNILID RDGHIKLTDF GLCTGFRWTH DSKYYQSGDH
PRQDSMDFSN EWGDPSNCRC GDRLKPLERR AARQHQRCLA HSLVGTPNYI APEVLLRTGY
TQLCDWWSVG VILFEMLVGQ PPFLAQTPLE TQVKV
//