ID   G3TZQ8_LOXAF            Unreviewed;       260 AA.
AC   G3TZQ8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Calcium homeostasis modulator family member 4 {ECO:0000313|Ensembl:ENSLAFP00000021066.1};
GN   Name=CALHM4 {ECO:0000313|Ensembl:ENSLAFP00000021066.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021066.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000021066.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021066.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000021066.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021066.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CALHM family.
CC       {ECO:0000256|ARBA:ARBA00008497}.
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DR   AlphaFoldDB; G3TZQ8; -.
DR   Ensembl; ENSLAFT00000029467.1; ENSLAFP00000021066.1; ENSLAFG00000027569.1.
DR   GeneTree; ENSGT01030000234610; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029569; CALHM.
DR   PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR   PANTHER; PTHR32261:SF5; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4; 1.
DR   Pfam; PF14798; Ca_hom_mod; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        55..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        106..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   260 AA;  29253 MW;  12973DF1E6F5DB6D CRC64;
     QYLSIQTNLK FLSITCKVKR SGTFINSLIA ILTIGGQQLL SSFTFSCPCQ VGKNFYYGSA
     FLVIPALILL IAGYALRSQM WTITSEYCCS CAPPCRQISP LERKLACLRF FSITGRALVA
     PLTWLAVTLL RGTYYECAAS EFTSVDHYPA FDNISASKRE EILAGFPCCR SAPSDVILVR
     DEVALLHRYQ SQMLGWILIT LAIIAALVSR CLARCCSPLT SLQHHYWTTH LNNERELFEQ
     VAEQHSKLLI MQRIKKIFGF
//