ID G3U0G8_LOXAF Unreviewed; 869 AA.
AC G3U0G8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Adhesion G protein-coupled receptor D1 {ECO:0000313|Ensembl:ENSLAFP00000021326.1};
GN Name=ADGRD1 {ECO:0000313|Ensembl:ENSLAFP00000021326.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021326.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000021326.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021326.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000021326.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021326.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR AlphaFoldDB; G3U0G8; -.
DR Ensembl; ENSLAFT00000032649.1; ENSLAFP00000021326.1; ENSLAFG00000000719.3.
DR GeneTree; ENSGT00940000159783; -.
DR HOGENOM; CLU_008509_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 564..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 561..805
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 828..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 94753 MW; 90D3569311067EA5 CRC64;
GFEVLASASH YWPLERVDGI HELQDTTGAS RAHNLTALLP HNSTFVYTND SAYSNSSATV
DIVEGKVNKG IYLKEEKGVT LLYYGSVRNS CISDPSQCGP EGVSFSFFWK TQGELSRPTP
FAYGGQVISN GFKVCSNGGK GSVELYTREN SMTWTATFSP PGPYWTHVLF TWKSKEGLKV
YVNGTLSTSD PSGKVSHAYG DPNANLVIGA EQDQTRRYEN GAFDEFIIWE RALTPDEVAM
YFTAAVGKHM ALSSTPPSFL VTPTVMPTDA YHPIITNLTE ERRKFQSPGI VLSYLQNVSL
HLPNESLSQE TARNLTETFL KTVGEVLLLP SWTDESEDQA AVLGLIDTID TVMRHISANL
HTHEPQVTIA GSSSMAEYSV AKVLSGTMNA SHYRFPAQGH SYVQIPHEAF HSQAWTTIGG
LLYHTVHFSL SNIHPDNTRI AEAAKHQGCL MSAASPLISL EVSPPPALAQ TLSGSPLVTV
HLTHILTQKQ YSRATNESNQ VFWYCAFLDF SSGKGVWSNE GCALTEGNLS YSVCSCTHLT
NFAVLMQVVP LELAHGHQVA LSSISYIGCS LSVICLTATL ATFAVLSSVS TIRSQRYHIH
ANLSFAVLVA QVLLLVSFQF HPGTTPCRVL AVLLHYFFLS AFAWMLVEGL HLYSMVIKVF
GSEDSKHLCY YGVGWGFPLL TCIISVSSAM DSYGASDNCW LSLGTGAIWA FVAPALLVIV
VNVGILVAVT RVISQISADN YKIHGDPNAF KLTVKAVAVL LPILGTSWVF GVLAVNDQAV
VFQYMFAVLN SLQGLFIFLF HCLLNSEVRA AFKHKTKIWS LTSSSARSTH AKPFSSDIMN
GTRPATASSK LSPWDKSSLS SHRVDLSAV
//
