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Database: UniProt
Entry: G3U183_LOXAF
LinkDB: G3U183_LOXAF
Original site: G3U183_LOXAF 
ID   G3U183_LOXAF            Unreviewed;      4403 AA.
AC   G3U183;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   28-MAR-2018, entry version 43.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSLAFP00000021591};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSLAFP00000021591};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021591, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000021591}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021591};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000021591}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021591};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSLAFT00000029770; ENSLAFP00000021591; ENSLAFG00000006539.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3716   3735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3936   3956       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4010   4029       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4146   4167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4204   4225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4280   4303       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       32    242       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      458    658       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      773    997       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3459   3494       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2498   2518       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4403 AA;  501099 MW;  B0B971003D5DA57B CRC64;
     SSGILEVLHC VLVESPEALN IIKEGHIKSI ISLLDKHGRN HKVLDVLCSL CVCHGVAVRS
     NQHLICDNLL PGRDLLLQTR LVNHVSSMRP NIFLGVSEGS AQYKKWYYEL MVDHTEPFVT
     AEATHLRVGW ASTEGYSPYP GGGEEWGGNG VGDDLFSYGF DGLHLWSGCI ARTVSSPNQH
     LLRTDDVISC CLDLSAPSIS FRINGQPVQG MFENFNIDGL FFPVVSFSAG IKVRFLLGGR
     HGEFKFLPPP GYAPCYEAVL PKEKLKVEHS REYKQERTYT RDLLGPTVSL TQAAFTPIPV
     DTSQIVLPPH LERIREKLAE NIHELWVMNK IELGWQYGPV RDDNKRQHPC LVEFSKLPEQ
     ERNYNLQMSL ETLKTLLALG CHVGILDEHA DEKVKKMKLP KNYQLTSGYK PAPMDLSFIK
     LTPSQEAMVD KLAENAHNVW ARDRIRQGWT YGIQQDVKNR RNPRLVPYAL LDDRTKKSNK
     DSLREAVRTL LGYGYNLEAP DQDHESTAAR AEMCSGTGER FRIFRAEKTY AVKAGKWYFE
     FEAVTAGDMR VGWSRPGCQP DQELGSDERA FAFDGFKAQR WHQGNEHYGR SWQAGDVVGC
     MVDMNEHTMM FTLNGEILLD DSGSELAFKD IEVGDGFIPA CSLGVAQVGR MNFGKDVSTL
     KYFTICGLQE GYEPFAVNTN RDITMWLSKR LPQFLQVPSN HEHIEVTRID GTIDSSPCLK
     VTQKSFGSQN SSTDIMFYRL SMPIECAEVF SKTAAGGLPG ASLFGPKNDL EDYDADSDFE
     VLMKTAHGHL VPDRVDKEAT KSEFNNHKDY AQEKPSRLKQ RFLLRRTKPD YSTSHSARLT
     EDVLADDRDD YDYLMQTSTY YYSVRIFPGQ EPANVWVGWI TSDFHQYDTG FDLDRVRTVT
     VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE IGCVVDAASG LLTFTANGKE
     LSTYYQKVEP STKLFPAVFA QATSPNVFQF ELGRIKNVMP LSAGLFKSEH KNPVPQCPPR
     LHVQFLSHVL WSRMPNQFLK VDVSRISERQ GWLVQCLDPL QFMSLHIPEE NRSVDILELT
     EQEELLKFHY HTLRLYSAVC ALGNHRVAHA LCSHVDEPQL LYAIDNKYMP GLLRAGYYDL
     LIDIHLSSYA TARLMMNNEF IVPMTEETKS ITLFPDENKK HGLPGIGLST SLRPRMQFSS
     PSFVSISNEC YQYSPEFPLD ILKAKTIQML TEAVKESSLH ARDPVGGTTE FLFVPLIKLF
     YTLLIMGVFH NEDLKHVLQL IEPSVFKDAA TPEEDSVVLE KELSTEDWKL EGAGEEEAKG
     GRRPKEGLLQ MKLPEPVKLQ MCLLLQYLCD CQVRHRIEAI VAFSDDFVAK LQDNQRFRYN
     EVMQALNMSA ALTARKTKEF RSPPQEQINM LLNFKDDKSE CPCPEEIRDQ LLDFHEDLMT
     HCGIELDEDG SLDGNSDLTI RGRLLSLVEK VTYLKKKQAE KPIESDSKKS STLQQLISET
     MVRWAQESVI EDPELVRAMF VLLHRQYDGI GGLVRALPKT YTINSVSVED TINLLASLGQ
     IRSLLSVRMG KEEEKLMIRG LGDIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
     EITFPKMVAN CCRFLCYFCR ISRQNQKAMF DHLSYLLENS SVGLELTASP AMRGSTPLDV
     AAASVMDNNE LALALREPDL EKVVRYLAGC GLQSCQMLVS KGYPDIGWNP VEGERYLDFL
     RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG LLAAMEEAIK IAEDPSRDGP
     SPTSGSSKTP DTEGEEDDTI HMGNAIMTFY SALIDLLGRC APEMHLIHAG KGEAIRIRSI
     LRSLIPLADL VGVISIAFQM PTIAKDGNVV EPDMSAGFCP DHKAAMVLFL DRVYGIEDQD
     FLLHLLEVGF LPDLRAAASL DTAALSATDM ALALNRYLCT AVLPLLTRCA PLFAGTEHHA
     SLIDSLLHTV YRLSKGCSLT KAQRDSIEVC LLSICGQLRP SMMQHLLRRL VFDVPLLNEH
     AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR KLFWGIFDAL SQKKYEQELF
     KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSVDSEGNFN PQPVDTSNIT IPEKLEYFIN
     KYAEHSHDKW SMDKLANGWI YGEVYSDSSK VQPLMKPYKL LSEKEKEIYR WPIKESLKTM
     LAWGWRIERT REGDSMALYN RTRRISQTSQ VSIDITHGYS PRAIDMSNVT LSRDLHAMAE
     MMAENYHNIW AKKKKMELES KGGGNHPLLV PYDTLTAKEK AKDREKAQDI LKFLQINGYA
     VSSSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRSK GEPFPYEQEI
     KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE KEMVTSLFCK LGVLVRHRIS
     LFGNDATSIV NCLHILGQTL DARTVMKTGL ESVKSALRAF LDNAAEDLEK TMENLKQGQF
     THTRNQPRGV TQIINYTTVA LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYTL
     GTSKSIYVER QRSALGECLA AFAGAFPVAF LETHLDKHNV YSIYNTKSSR ERAALNLPSN
     VEDVCPNIPS LEKLMDEIVE LAESGIRYTQ MPHVMEVILP MLCSYMSRWW EHGPENNPER
     AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIINKV KPQLLKTHFL
     PLMEKLKKKA ALVVSEEDHM KAEARGDMSE AELLILDEFT TLARDLYAFY PLLIRFVDYN
     RAKWLKEPNP EAEELFRMVA EVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS
     KAAVSDQERK KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKNRFSLKD
     TEDEVRDIIR NNIHLQGKLE DPAIRWQMAL YKDLPNRTED TSDPEKTVER VLDIANVLFH
     LEQVEHPQRS KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE
     EHYFEDKLIE DLAKPGAEPP EEDEGTKRVD PLHQLILLFS RTALTEKCKL EEDFLYMAYA
     DIMAKSCHDE EDDDGEEEVK SFEVTGSQRS KEKEMEKQKL LYQQARLHDR GAAEMVLQTI
     SASKGEMGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKEK KDVGFFQSLA GLMQSCSVLD
     LNAFERQNKA EGLGMVTEEG SGEKVLQDDE FTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN
     NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI
     QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL QKDMVVMLLS
     MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS
     KRDFHKAMES HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI GFNVAVLLTN
     LSEHMPNDTR LQTFLELAES VLNYFQPFLG RIEIMGSAKR IERVYFEISE SSRTQWEKPQ
     VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLNER STNKEESEKE
     KPEEQEPRMG FFSIRTVKSA LFALRYNILT LMRMLSLKSL KKQMKKMKKM TMKDMVTAFF
     SSYWSIFLNL LHFVASVFRG FFRIVCSLLL GGSLVEGAKK IKVAELLANM PDPTQDEVRG
     DGEDGERKPM EVALPSEDLT DLKELTEESD LLSDIFGLDL KREGGQYKLI PHNPNAGLSD
     LMSNPVPIPE VQEKFQQLSE LQLKCGKDKK TKSEPEKAEG EDGEKEEKAK EDKGKQKLRQ
     LHTHRYGEPE VPESAFWKKI IAYQQKLLNY FARNFYNMRM LALFVAFAIN FILLFYKVST
     SSVVEGKELP PRSSGENAKV SSLDSGSQRI IAVHYVLEES SGYMEPTLRI LAILHTVISF
     FCIIGYYCLK VPLVIFKREK EVARKLEFDG LYITEQPSED DIKGQWDRLV INTQSFPNNY
     WDKFVKRKVM DKYGEFYGRD RISELLGMDK AALDFSDARE KKKPKKDSSL SAVLNSIDVK
     YQMWKLGVVF TDNSFLYLAW YMTMSILGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG
     KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG
     GGIGDEIEDP AGDEYEIYRI IFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM
     ETKCFICGIG NDYFDTVPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY
     QERCWEFFPA GDCFRKQYED QLN
//
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