ID G3U1J6_LOXAF Unreviewed; 2844 AA.
AC G3U1J6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Spectrin repeat containing nuclear envelope protein 1 {ECO:0000313|Ensembl:ENSLAFP00000021704.1};
GN Name=SYNE1 {ECO:0000313|Ensembl:ENSLAFP00000021704.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021704.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000021704.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021704.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000021704.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021704.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR Ensembl; ENSLAFT00000036929.1; ENSLAFP00000021704.1; ENSLAFG00000008554.4.
DR GeneTree; ENSGT00940000154481; -.
DR HOGENOM; CLU_000034_1_1_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 7.
DR Gene3D; 1.20.58.60; -; 14.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR PANTHER; PTHR21524:SF7; SPECTRIN REPEAT CONTAINING, NUCLEAR ENVELOPE 1; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 9.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 16.
DR SUPFAM; SSF46966; Spectrin repeat; 16.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..2793
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 2815..2844
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 2785..2844
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 210..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2267..2305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2717..2780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..102
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 545..572
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1076..1103
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1182..1212
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1836..1880
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2515..2542
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2271..2291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2844 AA; 326700 MW; 714C9DEBAA990CF1 CRC64;
MKLNECLEPG KSPESQMAEH QALMDEILML QDEINVLQSS LAEELVSESP ESDPAEQLAL
QSTLTVLAER MSTIKMKASG KRQLLEEKLN DQLEEQRQEQ ALQRYRCEAD ELNHWLLNTK
ATLDIALGTP KEPMDMEAQL VDCQNMLVEI EQKVVALSEL SVHNENLLLE GKAHTKDEAE
QLAVKLRTLK GSLLELQRAL YDKRLNIQGT TQEKEESDAD LTATQSPGVQ EWLTHARTTR
THQRQSSLQQ RKKQKLEQEL AEQKSLLRSV ASRGEEILSQ HSAAEASGAG SEKPDVLCQE
LGMEGEKSST EDQMRMKWES LHQEFSTKQK LLQNVLEQEQ EQVLYSRPNR LLSGAPLYKG
DGQAQDKSAV TSLLDGLNQA FEEVSSQGGG TKRQSIHLEQ KLYDGVSATS TWLDDVEERL
FVATALLPEE TETCLFNQET LAKDIKEMSE EMDRNKNLFS QAFPENGDNR DVIEDTLGCL
LGRLSLLDSV VNQRCHQMKE RLQQILNFQN DLKVLFTSLA DNKYIVLQKL ANVFEQPVAE
QIEAIQQAED GLKELDAGIT ELKRRGDKLQ IEQPSLQELS RLQDMYDELM VTIGSRRSGL
NQNLALKSQY ERALQDLADL LETGQEKMAG DQKIIVSSKE EVHQLLDKHK EYFQGLESHM
ILTETLFRKI ISFAVLKETQ FHEELMTQAS AVLKRAHKRG VELEYILETW SRLDEDHQEL
SRQLEVVESS IPSVGLVEES EDRLIDRITL YQHLKSSLNE YQPKLYQVLD DGKRLLISVS
CSDLESQLNH LGEHWLTNTS KVAKELHRLE TILKHWTRYQ SESAALIQWL QSAKDKLEFW
SQQSVTVPQE LEMVRDHLNA FLEFSKEVDA QSSLKSSVLS TGNQLLRFKK VDTATLRAEL
SHIDSQWTEL LTNIPVVQEK LHQLQMDKLP SRHAITEVMS WISLMESVIQ KDEENIKNAI
GYKEVHEYLQ KYKGFKIDIN CKQLTVDFVN QSVLQISSQD VESKRSDKTD FAEQLGAMNK
SWQILQGLVT EKIQLLEGLL ESWSEYENNV QGLRMWFETQ EKRLKQQHEI GDQAAVENAM
KDCQDLEDLI KAKEKEVETI EQNGFALIQN KKEEVSGVVK CTLQKLTETW ANLDHMAGQL
KILLKSVLDQ WSNYKVAFDE INSSLMEARY SLARFRLLTG SLEAVQVQVD NLQSLQDDLE
KQEQSLQKFG SITNLLLKEC HPPVTETLTN TLKEVNMRWN NLLEEIAEQL HASKALLQLW
QRYKDYTKQC ASTVQQQEDQ TNELLKAATN KDIADDEVAA WIQDCNDLLK GLGTVKDSLF
VLHELGEQLK QQVDPSAASA IQSDQVSLSQ HLSALEQALC KQQTVLQKKK KKAGVLDYET
FAKSLEGLEA WVVEAEEILQ GQDPSHSSDL STIQERMEEL KGQMLRFSSM SPDLDHLNEL
GYRLPLSDKE IKRMQNLNRH WSLISSQTTE RFSKLQSFLL QHQTFSEKCE TWMEFLVETE
QKLAVEISGK YEHLLEQRRA HELFQAEMFS RQQILHSIIV DGQRLLEQGQ VDDRDEFNLK
LTLLSNQWQG VIRRAQQRRG IIDSQIRQWQ RYREMAEKLR KWLVEVSYLP TSGLGSVPIP
LQQARTLFDE VQFKEKVFLR QQGSYILTVE AGKQLLLSAD SGAEAALQAE LTEVQERWKS
ASMCLDEQKK QLAFLLKDWE KCEKGIADSL EKLRSFKKKL SQPLPDHHEE LHAEQMRCKE
LENVVGSWTE DLKQLTLLKD TLSAYISAED ISILNERLEL LQRQWEELCH QLSLRRQQVS
ERLNEWAVFS EKNKELCEWL TQMESKVSQN GDILIEEMIE KLKKDYQEEI AVAQENKIQL
QQMGERLAKA SNESKASEIE YKLGKVNDRW QHLLDLIAAR VKKLKETLVA VQQLDKNMSS
LRTWLAHIEA ELAKPIVYDS CDSEEIQRKL SEQQELQRDI EKHSTGVASV LNLCEVLLHD
CDACATDTEC DSIQQATRNL DRRWRNICAV SMERRLKIEE TWRLWQKFLD DYSRFEDWLK
ISERTAAFPS SSGVLYTVAK EELKKFEAFQ RQVHESLTQL ELINKQYRRL ARENRTDSAC
SLKQMVHDGN QRWDNLQKRV TSILRRLKHF IGQREEFETA RDSILVWLTE MDLQLTNIEH
FSECDVQVKI KQLKAFQREI SLNHNKIEQI IAQGEQLIEK SEPLDAAVIE EELDELRRYC
QEVFGRVERY HKKLIRLPLP DEEHDLSDRE LELDDSAALS DLHWHDPSAD SVLSPQPSSN
PSLSLAQPLR SERSGRDTPA SVDSIPLEWD HDYDLSRDLE SAVSRTLHSE DEESQEDKDF
YLRGAVGLSD VVIPETPEAF VKLTENAIRN TSGGHSALES RIRQLDKALD DSHFRMQQTE
NIIRSKTPTG PELDASYKGY MKLLGECSGS IDSVKRLEHK LKEEEENFPG FVNLDSTETQ
TAGVIDRWEL IQAQALSKEL RMKQNLQKWQ QFNSDLNNTW AWLGETEEEL ERLQRLELST
DIQTIELQIK RLKELRKAVD HRKAIILSIN LCSSEFTQAD SKESRDLQDR LSQMNGRWDR
VCSLLEEWQG LLQDALMQCQ DFHEMSHGLL LMLENIDRRK NEIIPIDSNL DTEILQDHHK
QLTQIRHDLL ESQLKVASLQ DMSCQLLVNA EGADCLEAKE KVHVIGNRLK LLLKEVSRHI
KDLEKLLDMS SSQQDLSSWS SADELDTSGS MSPTSGRSTP NRQRTPRGKC SLSQPGPSVN
SPQSRSTKGG SDSSLSEPQP ARSGRAFLLR VLRAALPLQL LLLLLIGLAC LVPMSEEDYS
CALSNNFARS FHPMLRYTNG PPPL
//
