ID G3U233_LOXAF Unreviewed; 1213 AA.
AC G3U233;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Nuclear receptor binding SET domain protein 3 {ECO:0000313|Ensembl:ENSLAFP00000021891.1};
GN Name=NSD3 {ECO:0000313|Ensembl:ENSLAFP00000021891.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021891.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000021891.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021891.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000021891.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021891.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3U233; -.
DR Ensembl; ENSLAFT00000028853.1; ENSLAFP00000021891.1; ENSLAFG00000014727.4.
DR GeneTree; ENSGT00940000155355; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15649; PHD1_NSD3; 1.
DR CDD; cd15652; PHD2_NSD3; 1.
DR CDD; cd15658; PHD4_NSD3; 1.
DR CDD; cd15661; PHD5_NSD3; 1.
DR CDD; cd20163; PWWP_NSD3_rpt1; 1.
DR CDD; cd20166; PWWP_NSD3_rpt2; 1.
DR CDD; cd19212; SET_NSD3; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR041306; C5HCH.
DR InterPro; IPR047456; PHD2_NSD3.
DR InterPro; IPR047458; PHD4_NSD3.
DR InterPro; IPR047527; PHD5_NSD3.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR047451; PWWP_NSD3_rpt1.
DR InterPro; IPR047453; PWWP_NSD3_rpt2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047461; SET_NSD3.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22884:SF473; HISTONE-LYSINE N-METHYLTRANSFERASE NSD3; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF17982; C5HCH; 1.
DR Pfam; PF00855; PWWP; 2.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00249; PHD; 5.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00293; PWWP; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50812; PWWP; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 64..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..179
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 552..599
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 715..759
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 764..826
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 897..947
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 949..1066
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1073..1089
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1125..1172
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 189..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 838..865
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 194..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1213 AA; 137215 MW; B67D475B63239AD2 CRC64;
PQTVIPKKTG SPEIKLKITK TIQNGRELFE SSLCGDLLNE VQASEHTKSK HESRKEKRKK
RIRILRYNSF SSSQLVFVIL CCLLISPLSF ELKAAKQALP HTGRDQLILV HYNVGDLVWS
KVGTYPWWPC MVSSDPQLEV HTKINTREKS AREYHVQFFS NQPERAWVHE KRVREYKGHE
QYEELLAEAT KQASNHSEKQ KIRKPRPQRE RAQWDIGIAH AEKALKMTRE ERIEQYTFIY
IDKQPEAKKN VASKAEVKKT RRPRSVPNTQ TEQTNTGEAA SSPSSTEIRR HSQRRHTSVE
EEEPPPVTEK TWGLPLFKKK NVERGDGGRG GRRGMLNSTP LSKIKLILMQ IFYFCFLTEL
LFSSPDNFGA NYEDYLGSPG TEYNKSLKSQ INGLYHLLGS VEKKQQRRSI RTRSESEKST
EVVPKKKIKK EQVGFLHTEN FTQKMGLASD FRYISNQSSL LRLIAVKSFC ASEISDSCKP
LKKRSRASTD VEMTSSAYRD TSDSDSRGLS DLQVSFGKQV DSPSATADVD ISDVQSVDSS
LSRSSFGMTK KDAVCQICES TGDSLIPCEG ECCKHFHLEC LGLASLPDGK FICMECQTGQ
HPCFSCKVSG TDVKRCSVGT CGKFYHETCV RKFPTAIFES KGFRCPQHCC SACSMENPEK
PNSKIGRMMR CLRCPVAYHS GDACIAAGSI FVSSYVLICS NHSKRSSNSS SAVNVGFCFV
CARGGRLLCC ESCPASFHPE CLGIGMPEGC WNCDDCKAGR KLHYKQIVWV KLGNYRWWPA
ETCNPRSVPL NIQGLKHDLG DFPVFFFGSH DYYWVHQGRV FPYVEGDKSF AEGQTSINKT
FKKALEEAAK RFQELKAQRE SKEALEIEKN SRKPPPYKHI KANKVVGKVQ IQVADLSEIP
RCNCKPADEN PCGLESECLN RMLQYECHPQ VCPAGDRCQN QCFTKRLYPD AEIIKTERRG
WGLRTKRSIK KGEFVNEYVG ELIDEEECRL RIKRAHENSV TNFYMLTVTK DRIIDAGPKG
NYSRFMNHSC NPNCETQKWT VNGDVRVGLF ALCDIPAGME LTFNYNLDCL GNGRTECHCG
ADNCSGFLGV RPKSACASTT EEKARNAKLK QKRRKIKTEP KQMHEDYCFQ CGDGGELVMC
DKKDCPKAYH LICLNLTQPP YGKWECPWHQ CDECSSSAAS FCEFCPHSFC KDHEKGALVP
SALEGRLCCS EHD
//
