ID G3U2A7_LOXAF Unreviewed; 2642 AA.
AC G3U2A7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Filamin C {ECO:0000313|Ensembl:ENSLAFP00000021965.1};
GN Name=FLNC {ECO:0000313|Ensembl:ENSLAFP00000021965.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000021965.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000021965.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021965.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000021965.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000021965.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR Ensembl; ENSLAFT00000035156.1; ENSLAFP00000021965.1; ENSLAFG00000008705.4.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR CDD; cd21314; CH_FLNC_rpt2; 1.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 44..150
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 167..270
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 278..376
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 378..476
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 477..573
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 574..666
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 670..766
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 767..869
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 870..968
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 969..1064
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1065..1157
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1158..1252
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1253..1352
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1353..1445
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1446..1541
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1542..1638
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1651..1742
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1783..1852
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1852..1944
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1942..2031
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2034..2126
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2124..2223
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2226..2318
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2320..2413
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2417..2509
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2547..2641
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2642 AA; 281728 MW; D3E56F6DC7716230 CRC64;
QRSCRARMMN NSGYSEPAGL GLADEADEMP STEKDLAEDA PWKKIQQNTF TRWCNEHLKC
VGKRLTDLQR DLSDGLRLIA LLEVLSQKRM YRKFHPRPNF RQMKLENVSV ALEFLEREHI
KLVSIDSKAI VDGNLKLILG LIWTLILHYS ISMPMWEDED DEDARKQTPK QRLLGWIQNK
VPQLPITNFN RDWQDGKALG ALVDNCAPGL CPDWEAWDPN QPVENAREAM QQADDWLGVP
QVIAPEEIVD PNVDEHSVMT YLSQFPKAKL KPGAPVRSKQ LNPKKAIAYG PGIEPQGNTV
LQPAHFTVQT VDAGVGEVLV YIEDPEGHTE EAKVVPNNDK DRTYAVSYVP KVAGLHKVTV
LFAGQNIERS PFEVNVGMAL GDASKVSARG PGLEPVGNVA NKPTYFDIYT AGAGTGDVAV
VIVDPQGRRD TVEVALEDKG DSTFRCTYRP VMEGPHTVHV AFAGAPITRS PFPVHVAEAC
NPNACRASGR GLQPKGVRVK EVADFKVFTK GAGSGELKVT VKGPKGTEEP VKVREAGDGV
FECEYYPVVP GKYVVTITWG GYAIPRSPFE VQVSPEAGVQ KVRAWGPGLE TGQVGKSADF
VVEAIGTEVG TLGFSIEGPS QAKIECDDKG DGSCDVRYWP TEPGEYAVHV ICDDEDIRDS
PFIAHIQPAP PDCFPDKVKA FGPGLEPTGC IVDKPAEFTI DARLAGKGDL KLYAQDAEGC
PIDVKVIPNG DGTFRCSYVP TKPIKHTIII SWGGVNVPKS PFRVNVGEGS HPERVKVYGP
GVEKTGLKAN EPTYFTVDCS EAGQGDVSIG IKCAPGVVGP AEADIDFDII KNDNDTFTVK
YTPPGPGRYT IMVLFANQEI PASPFHIKVD PSHDASKVKA EGPGLNRTGV EVGKPTHFTV
LTKGAGKAKL DVHFAGAAKG EAVRDFEIID NHDYSYTVKY TAVQQGNMAV TVTYGGDPVP
KSPFVVNVAP PLDLSKVKVQ GLNSKVAVGQ EQAFSVTTRG AGGQGQLDVR MTSPSRRPIP
CKLEPGGGAD TQAVRYMPPE EGPYKVDITY DGHLVPGSPF TVEGVLPPDP SKVCAYGPGL
KGGLVGTPAP FSIDTKGAGT GGLGLTVEGP CEAKIECQDN GDGSCAVSYL PTEPGEYTIN
ILFAETHIPG SPFKATIRPV FDPSKVRASG PGLERGKVGE AATFTVDCSE AGEAELTIEI
LSDAGVKAEV LIHNNADGTY HITYSPAFPG TYTITIKYGG HPVPKFPTRV HVQPAVDTSG
IKVFGPGVEP HGVLREVTTE FTVDARSLTA MGGNHVTARV LNPSGAKTDT YVTDNGDGTY
RVQYTAYEEG VHLVEVRYDD VAVPKSPFRV GVTEGCDPTR VRAFGPGLEG GLVNKANRFT
VETRGAGTGG LGLAIEGPSE AKMSCKDNKD GSCTVEYIPF TPGDYDVNIT FGGRPIPGSP
FRVPVKDVVD PGKVKCSGPG LGAGVRARVP QTFTVDCSQA GRAPLQVAVL SPTGVAEPVE
VRDKGDGTHT VHYTPATDGP YTVAVKYADQ EVPRSPFKIK VLPAHDASKV RASGPGLNAS
GIPASLPVEF TIDARDAGEG LLTVQILDPE GKPKKANIRD NGDGTYTVSY LPDMSGRYTI
TIKYGGDEIP YSPFRIHALP TGDASKCLVT VSIGGHGLGA CLGPRIQIGE ETVITVDAKA
AGKGKVTCTV STPDGAELDV DVVENHDGTF DIYYTAPEPG KYVITIRFGG EHIPNSPFHV
LSFCGDSPGV RLPQLMPVPS YPPQATEEPV VPVEPMESML RPFNLVIPFT VQKGELTGEV
RMPSGKTARP NITDNKDGTI TVRYAPTEKG LHHMGIKYDG NHIPGSPLQF YVDAINSRHV
SAYGPGLSHG MVNKPATFTI VTKDAGEGGL SLAVEGPSKA EITCKDNKDG TCTVSYLPTA
PGDYSIIVRF DDKHIPGSPF TAKITGDDSM RTSQLNVGTS TDVSLKITES DLSLLTASIR
APSGNEEPCL LKRLPNRHIG ISFTPKEVGE HVVSVRKSGK HVTNSPFKIL VGPSEIGDAS
KVRVWGKGLS EGQTFQVAEF IVDTRNAGYG GLGLSIEGPS KVDINCEDME DGTCKVTYCP
TEPGTYIINI KFADKHVPGS PFTVKVTGEG RMKESITRRR QAPSIATIGS TCDLNLKIPG
EASSQDMAAQ VTSPSGKTEA AEIVEGEDSA YSVRFVPQEM GPHTVAVKYR GQHVPGSPFQ
FTVGPLGEGG AHKVRAGGTG LERGVAGMPA EFSIWTREAG AGGLSIAVEG PSKAEIAFED
RKDGSCGVSY VVQEPGDYEV SIKFNDEHIP DSPFVVPVAS LSDDARRLTV TSLQETGLRV
NQPASFAVQL NGARGVIDAR VHTPSGAVEE CYVSELDSDK HTIRFIPHEN GVHSIDVKFN
GAHIPGSPFK IRVGEQSQAG DPGLVSAYGP GLEGGTTGVS SEFIVNTLNA GSGALSVTID
GPSKVQLDCR ECPEGHVVTY TPMAPGNYLI AIKYGGPQHI VGSPFKAKVT GPRLSGGHSL
HETSTVLVET VTKSSSSRGS SYSSIPKFSS DASKVVTRGP GLSQAFVGQK NSFTVDCSKA
GTNMMMVGVH GPKTPCEEVY VKHMGNRVYN VTYTVKEKGD YILIVKWGDE SVPGSPFKVN
VP
//
