ID G3U2K0_LOXAF Unreviewed; 1987 AA.
AC G3U2K0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Myosin heavy chain 10 {ECO:0000313|Ensembl:ENSLAFP00000022058.1};
GN Name=MYH10 {ECO:0000313|Ensembl:ENSLAFP00000022058.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000022058.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000022058.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022058.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000022058.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000022058.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSLAFT00000037088.1; ENSLAFP00000022058.1; ENSLAFG00000005826.4.
DR GeneTree; ENSGT00940000155159; -.
DR HOGENOM; CLU_000192_4_4_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14920; MYSc_Myh10; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF24; MYOSIN-10; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF50084; Myosin S1 fragment, N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 42..92
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 96..794
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 672..694
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1138..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1708..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1885..1987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1708..1728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1885..1926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1961..1976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 189..196
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1987 AA; 230474 MW; 8B07CF34A5D30047 CRC64;
RGDCSWILLL TMAQRTGLED PERYLFVDRA VIYNPATQAD WTAKKLVWIP SERHGFEAAS
IKEERGDEVM VELAENGKKA MVNKDDIQKM NPPKFSKVED MAELTCLNEA SVLHNLKDRY
YSGLIYTYSG LFCVVINPYK NLPIYSENII EMYRGKKRHE MPPHIYAISE SAYRCMLQDR
EDQSILCTGE SGAGKTENTK KVIQYLAHVA SSHKGRKDHN IPGELERQLL QANPILESFG
NAKTVKNDNS SRFGKFIRIN FDVTGYIVGA NIETYLLEKS RAVRQAKDER TFHIFYQLLS
GAGEHLKSDL LLEGFSNYRF LSNGYIPIPG QQDKDNFQET MEAMHIMGFS HEEILSMLKV
VSSVLQFGNI SFKKERNTDQ ASMPENTVAQ KLCHLLGMNV MEFTRAILTP RIKVGRDYVQ
KAQTKEQADF AVEALAKATY ERLFRWLVHR INKALDRTKR QGASFIGRVF GKRLHIFQLN
SFEQLCINYT NEKLQQLFNH TMFILEQEEY QREGIEWNFI DFGLDLQPCI DLIERPANPP
GVLALLDEEC WFPKATDKTF VEKLVQEQGS HSKFQKPRQL KDKADFCIIH YAGKVDYKAD
EWLMKNMDPL NDNVATLLHQ SSDRFVAELW KDVDRIVGLD QVTGMTETAF GSAYKTKKGM
FRTVGQLYKE SLTKLMATLR NTNPNFVRCI IPNHEKRAGK LDPHLVLDQL RCNGVLEGIR
ICRQGFPNRI VFQEFRQRYE ILTPNAIPKG FMDGKQACER MIRALELDPN LYRIGQSKIF
FRAGVLAHLE EERDLKITDI IIFFQAVCRG YLARKAFAKK QQQLSALKVL QRNCAAYLKL
RHWQWWRVFT KVKPLLQVTR QEEELQAKDE ELLKVKEKQT KVEGELEEME RKHQQLLEEK
NILAEQLQAE TELFAEAEEM RARLAAKKQE LEEILHDLES RVEEEEERNQ ILQNEKKKMQ
AHIQDLEEQL DEEEGARQKL QLEKVTAEAK IKKMEEEILL LEDQNSKFIK EKKLMEDRIA
ECSSQLAEEE EKAKNLAKIR NKQEVMISDL EERLKKEEKT RQELEKAKRK LDGETTDLQD
QIAELQAQID ELKIQLAKKE EELQGALARG DDETLHKNNA LKVVRELQAQ IAELQEDFES
EKASRNKAEK QKRDLSEELE ALKTELEDTL DTTAAQQELR TKREQEVAEL KKALEEETKN
HEAQIQDMRQ RHATALEELS EQLEQAKRFK ANLEKNKQGL ETDNKELACE VKVLQQVKAE
SEHKRKKLDA QVQELHAKVS EGDRLRVELA EKANKLQNEL DNVSTLLEEA EKKGVKFAKD
AAGLESQLQD TQELLQEETR QKLNLSSRIR QLEEEKNSLQ EQQEEEEEAR KNLEKQVLAL
QSQLTDTKKK VDDDLGTIES LEEAKKKLLK DVEALSQRLE EKALAYDKLE KTKNRLQQEL
DDLTVDLDHQ RQIVSNLEKK QKKFDQLLAE EKNISARYAE ERDRAEAEAR EKETKALSLA
RALEEALEAK EEFERQNKQL RADMEDLMSS KDDVGKNVHE LEKSKRALEQ QVEEMRTQLE
ELEDELQATE DAKLRLEVNM QAMKAQFERD LQTRDEQNEE KKRLLIKQVR ELEAELEDER
KQRALAVASK KKMEIDLKDL EAQIEAANKA RDEVIKQLRK LQAQMKDYQR ELEEARASRD
EIFAQSKESE KKLKSLEAEI LQLQEELASS ERARRHAEQE RDELADEIAN SASGKSALLD
EKRRLEARIA QLEEELEEEQ SNMELLNDRF RKTTLQVDTL NTELAAERSA AQKSDNARQQ
LERQNKELKA KLQELEGTVK SKFKATISAL EAKIGQLEEQ LEQEAKERAA ANKLVRRTEK
KLKEIFMQVE DERRHADQYK EQMEKANARM KQLKRQLEEA EEEATRANAS RRKLQRELDD
ATEANEGLSR EVSTLKNRLR RGGPISFSSS RSGRRQLHIE GASLELSDDD TESKTSDVNE
TQPPPSE
//
