ID   G3U667_LOXAF            Unreviewed;       140 AA.
AC   G3U667;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=RAB5 interacting factor {ECO:0000313|Ensembl:ENSLAFP00000023325.1};
GN   Name=RAB5IF {ECO:0000313|Ensembl:ENSLAFP00000023325.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023325.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000023325.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023325.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000023325.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023325.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the EMC6 family.
CC       {ECO:0000256|ARBA:ARBA00009436}.
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DR   AlphaFoldDB; G3U667; -.
DR   STRING; 9785.ENSLAFP00000023325; -.
DR   Ensembl; ENSLAFT00000035933.1; ENSLAFP00000023325.1; ENSLAFG00000023111.2.
DR   eggNOG; KOG3415; Eukaryota.
DR   GeneTree; ENSGT00390000004786; -.
DR   HOGENOM; CLU_165179_0_0_1; -.
DR   InParanoid; G3U667; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005746; C:mitochondrial respirasome; IEA:Ensembl.
DR   GO; GO:0160064; C:multi-pass translocon complex; IEA:Ensembl.
DR   GO; GO:0097250; P:mitochondrial respirasome assembly; IEA:Ensembl.
DR   GO; GO:0160063; P:multi-pass transmembrane protein insertion into ER membrane; IEA:Ensembl.
DR   InterPro; IPR029008; EMC6-like.
DR   InterPro; IPR010742; RCAF1.
DR   PANTHER; PTHR12906; PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR12906:SF0; RESPIRASOME COMPLEX ASSEMBLY FACTOR 1; 1.
DR   Pfam; PF07019; EMC6; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   140 AA;  15272 MW;  46CE4CBD5105304C CRC64;
     MSGGRRKEEP PQPQLANGAL KVSVWSKVLR SDAAWEDKDE FLDVIYWFRQ IIAVLLGVIW
     GVLPLRGFLG IAGSFGSSFT QPSTMTDGVQ PSPAPCLKDP LSYSTETRCR GTPAGSLEDA
     CFLDRESLCW ASVYSARVGT
//