ID G3U6G6_LOXAF Unreviewed; 473 AA.
AC G3U6G6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Transmembrane protein 181 {ECO:0000313|Ensembl:ENSLAFP00000023424.1};
GN Name=TMEM181 {ECO:0000313|Ensembl:ENSLAFP00000023424.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000023424.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000023424.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023424.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000023424.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000023424.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G3U6G6; -.
DR STRING; 9785.ENSLAFP00000023424; -.
DR Ensembl; ENSLAFT00000035842.1; ENSLAFP00000023424.1; ENSLAFG00000007610.4.
DR eggNOG; ENOG502QPXU; Eukaryota.
DR GeneTree; ENSGT00390000007183; -.
DR HOGENOM; CLU_040299_0_0_1; -.
DR InParanoid; G3U6G6; -.
DR OMA; QQLWVIA; -.
DR TreeFam; TF324083; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR InterPro; IPR040416; TMEM181.
DR InterPro; IPR047843; WLS-like_TM.
DR PANTHER; PTHR31918; TRANSMEMBRANE PROTEIN 181; 1.
DR PANTHER; PTHR31918:SF1; TRANSMEMBRANE PROTEIN 181; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..421
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
SQ SEQUENCE 473 AA; 54770 MW; ACC83BE473BC33DE CRC64;
SPRLAPMRLY TLSKRHFVLV FVVFFICFGL TVFVGIKGPK VIQTSAANFS LNSKKLKPIQ
ILSNPLSTYN QQLWLTCVVE LNQSKETSFQ MSFPMTVKVD GVAQDGTVMF IHNKVHNRTR
TLTCAGKCAE IIVAHLGYLN YTQYTVTVGF EHLKLSIKEM NFTWKTYDPK FSQLEIWFRF
VFVVLTFIVT CLFAHSLRKF SMRDWGIEQK WMSILLPLLL LYNDPFFPLS FLVNSWLPGM
LDDLFQSLFL CALLLFWLCV YHGIRVQGER KCLTFYLPKF FIVGLLWLAS VTLGIWQTVN
ELHDPMYQYR VDTGNFQGFS VVFPVSSRGF ALLLFLLLRS CLMEFFLSFA DLRLKFLTAL
TFVVLVISIV ILYLRFGAQV LQDNFVAELS THYQNYTEFL SFYGLLNFYL YTLAFVYSPS
KNALYESQLK DNPAFSMLND SDDDVIYGSD YEEMPLQNGQ AIRAKYKEES DSD
//
