ID G3U8C3_LOXAF Unreviewed; 471 AA.
AC G3U8C3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Keratin, type I cytoskeletal 10 {ECO:0000256|ARBA:ARBA00040327};
DE AltName: Full=Cytokeratin-10 {ECO:0000256|ARBA:ARBA00041708};
DE AltName: Full=Keratin-10 {ECO:0000256|ARBA:ARBA00042491};
GN Name=KRT10 {ECO:0000313|Ensembl:ENSLAFP00000024081.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024081.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024081.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024081.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024081.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024081.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted, extracellular
CC space {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; G3U8C3; -.
DR STRING; 9785.ENSLAFP00000024081; -.
DR Ensembl; ENSLAFT00000035060.1; ENSLAFP00000024081.1; ENSLAFG00000011407.2.
DR eggNOG; ENOG502QV0B; Eukaryota.
DR GeneTree; ENSGT00940000160849; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; G3U8C3; -.
DR OMA; QGQPRDY; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0051290; P:protein heterotetramerization; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF137; KERATIN, TYPE I CYTOSKELETAL 10; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 127..441
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..426
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 439..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 50476 MW; 97A20FE27DAFD9E4 CRC64;
QYSSSKQYSS SRCGGRSGGG GGSSIKISSS KGSIGGGFVP GGFSCGSFSR GSSSGVCFGG
SSGGYGGIGG GLGGGSFGGS IFGGGYGGGS FGGGYGGGGF GGGSFSGGSF GGFGGGFGEG
GLLSGNEKLT MQNLNDRLAS YLDKVRALEE SNYELEGKIK EWYEKHGNVG QREPRDYSKY
FQIIEELKNQ IINLTTDNAN ILIQIDNARL AADDFRLKYE NEVALRQSVE ADINGLRRVL
DELTLARADL EMQIESLTEE VAYLKKNHEQ EMRDLQNVST GDVNVEMNAA PGVDLTELLN
NMRSQYEQLA EQNRRDAEAW FNEKSKELTI EIDTNIEQIS SYQTEITELR RTVQALEIEL
QSQLALKQSL EASLAETEGR YCVQLSQIQA QISALEEQLQ QIRAEIECQN AEYQQLLDIK
IRLENEIQTY RSLLEGEGGS SGGVQTGSIS YKVSSSSSTS VGESSSKGAR S
//
