ID G3U8G5_LOXAF Unreviewed; 478 AA.
AC G3U8G5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Rho GTPase activating protein 20 {ECO:0008006|Google:ProtNLM};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024123.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024123.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024123.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024123.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024123.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3U8G5; -.
DR STRING; 9785.ENSLAFP00000024123; -.
DR Ensembl; ENSLAFT00000028779.1; ENSLAFP00000024123.1; ENSLAFG00000029965.1.
DR eggNOG; KOG4724; Eukaryota.
DR GeneTree; ENSGT00940000154633; -.
DR HOGENOM; CLU_008526_1_0_1; -.
DR InParanoid; G3U8G5; -.
DR OMA; GHENPYA; -.
DR TreeFam; TF352861; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF37; 1700006A11RIK PROTEIN; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 12..106
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 115..219
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 289..474
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 478 AA; 54060 MW; 1422FC14519B022C CRC64;
ERTTLSEGPN RTLLIHGPVE FKRGWRRQKR HLFLFSDLLL VSNSKYRKTF KIKDKIPLNT
MWMTDCDDTN AKRSLVLGWP TVNFTATFSS SEQKEQWRSS LRRYINLAKE KDHPKSIPLK
IFAEDIENCA CPISLTVTNS DTTNDIIDKS LPMLGITVSK GSKSDYQLWV SSGKKEAPFP
LIGHEHPYGI KMSHLQATAL LPHRLRGSIS SSTLQEPFLL EQPFPEMGGP FVLKPRRPLR
SQEHKNAGQR TGEKKWPMVN WAFRRNPSTC QDNVCRALPS PEPGKLFGVS LKDVCPGDDL
PTPLRDMLFF LNQKGPLTEG IFRISASVRA CGALKQKLNS GEKVNWEDEP VLVVASVLKD
FFRNIQESVF SSGLYYQWLT VIDEGNEEEK ITGIQRLLDQ LPKANVVLLR YLFGALHNIE
QHSASNQMTA YNLSVCIAPS ILWSSTSCSP GLENELTKKI SLVQFVIKNC LNIFGKDI
//
