ID G3U8P5_LOXAF Unreviewed; 293 AA.
AC G3U8P5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Thyrotropin-releasing hormone receptor {ECO:0000256|ARBA:ARBA00018873};
DE AltName: Full=Thyroliberin receptor {ECO:0000256|ARBA:ARBA00032251};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024203.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024203.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024203.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024203.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024203.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand
CC binding, this G-protein-coupled receptor triggers activation of the
CC phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
CC {ECO:0000256|ARBA:ARBA00004100}.
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DR AlphaFoldDB; G3U8P5; -.
DR STRING; 9785.ENSLAFP00000024203; -.
DR Ensembl; ENSLAFT00000037203.1; ENSLAFP00000024203.1; ENSLAFG00000029277.1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01100000263484; -.
DR HOGENOM; CLU_009579_6_5_1; -.
DR InParanoid; G3U8P5; -.
DR OMA; LGTSAYC; -.
DR TreeFam; TF326170; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004997; F:thyrotropin-releasing hormone receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002120; TRH_rcpt_1.
DR PANTHER; PTHR46061; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR PANTHER; PTHR46061:SF1; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00751; THYROLIBRINR.
DR PRINTS; PR01846; TRHRFAMILY.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..293
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 31546 MW; BD8851B508A2B015 CRC64;
LENTAGSPER ANKSGLGTMP RPPLPVQEVI LALVPLVCAV GVAGNDKVAL VVVWSRLMIT
PTNCYLVSLA AAELLVLLAA GVPTVAKVMS AWDWVFSRMG CLGITYLQYV GINSSSSSIT
AFTVERYLCS PLHARAPCTG ARAKRIAALV CLLRALALPC VRVQCDYRVS RSLYLPLYFL
DFALFYALPL GLATALSALI ARNLFVCGLP TGGPGRSGSA HQGGSAGQAR FRSRARKGAL
NSRKQVTKML AVVVLFALLW LPYRTLVVVN SFLSLSYRNL SFLLFCCLCN HLH
//
