ID G3U9X5_LOXAF Unreviewed; 2949 AA.
AC G3U9X5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024633.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000024633.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024633.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000024633.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024633.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}.
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC {ECO:0000256|ARBA:ARBA00038258}.
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DR STRING; 9785.ENSLAFP00000024633; -.
DR Ensembl; ENSLAFT00000028278.1; ENSLAFP00000024633.1; ENSLAFG00000031062.1.
DR eggNOG; ENOG502QQH0; Eukaryota.
DR GeneTree; ENSGT00940000154467; -.
DR InParanoid; G3U9X5; -.
DR OMA; SGTHHAE; -.
DR TreeFam; TF338665; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003303; Filaggrin.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR22571:SF51; FILAGGRIN; 1.
DR PANTHER; PTHR22571; FILAGGRIN-RELATED; 1.
DR Pfam; PF03516; Filaggrin; 20.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 96..2949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..119
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1442..1459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1663..1697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1716..1733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1752..1781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1782..1813
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1814..1848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1879..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1937..1987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1988..2013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2014..2034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2035..2056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2057..2107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2143..2177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2178..2196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2211..2293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2294..2324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2325..2377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2378..2392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2393..2438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2439..2455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2457..2507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2508..2531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2532..2578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2579..2593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2594..2622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2642..2675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2676..2702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2703..2720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2721..2771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2796..2839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2840..2857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2862..2949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2949 AA; 314261 MW; 17400B00BD09A804 CRC64;
MSTLLENITA IIDLFQQYSS NDKENDTLSK KELEELLETE FQPILENPND PDTADDFMRI
LDLDHNKKVD FTEFFLMVFK LAQAYYESTK RQNFKASGPK QKKYGHKCSS LSRRHRQTGK
KSLTTTDKKK HRSSSKNKGR RDDSCPSGHR EKNGKNHHHH TGKNKRSSFT DLGEETNISS
ISQKREVGDE HNYGSENRER GSARWEYSRG RQGSRHGHSV DSSTHSDSDQ GEISSEGRSR
SSTKSRQQSH QHNSADHPRH SGTGRGRSTI ESGAGSHRGS SVGQASDSEG QSEDSQRQSG
SPSGHHHGSN QGQSRDSSRH SGYHQGHRTT APHSHSGDSS RHSGSHQGET SAHGQSRSST
RGRQEARQEH SADRSRRSGP GHAQSSVESG EGRHRGSSVS QASDSKGQSE DSHRQSGYAS
THYHGSTHGQ SRDSSRHSGS HQGHRADASQ SHSAHGHSDS TARGRQGSSH GHSVDSSRHS
SSHQGETSAH GQPRSSTRAR HHQGSTHGQS RDYSGHSGSH QGHRADASQS HSAHGNSDST
ARGRQAYSHR QSVDSSRHSG SHQGETSAHA DRSTHSGAGH THSSVESGEG RHRGSSVSQA
TDSEGQSEDS HRQSGYASTH YHGSTHGQSR DTSRHSGSHQ GHRADASQSH SAHGHSDSTV
RGRQGSSHGH SVDSSRHSSF HQGETSACGQ PRSSTRGRQE SHQKHSGERS RDSGTGRGQS
PNESGAGRHR ESSVSQASDS EGQSDDSQTQ SGYASRHHQG STHGQSRDNS RNSRSHQGHR
DDGPQSHSAH GHSDSTATGR QGSSHGQSVD SSRHLGSQQG ETSAHRQSRS STRGRQESHL
EHSTDRSRHS GAGHAQSSFE SRAVRHRAPS VSQASDSEGQ SEDSHRQSGY ASTHYHGSTH
GQSRDSSRHS GSQQGHRADG PQSHPAHVHS DSTARGRQGS SHGQSVDTSR HSGSHQRETS
AHGQSRSSTR GRQESRQEHS ADHSRHSGDG RGQSSAESGE GRHRGSSVSQ ASDSEGQSED
SHRQSGSASG HHHGSNHGQS RDSSRHSGYH QGHRATAPHS HSTHGHSDST AIGSQGSSYG
QSVDSSRHSG SHQRETFTHG QSRSSTRGRQ ESRQEHSADR SRHSGDGHGQ SSGHDSEGQS
EDSHRQSGYA STHYHGSTHG QSGDSSRHSG SHQGETSAHA DRSRHSGAGH AQSSLESGAV
RHRGSSVSQA SDSEGQSEDS HRQSGYASTH YHGSTHGQAR DSSRHSRSHQ GHRADASQSH
SAHGHSESTA RGRQGSSHGY SVDSSRHSSS HQGETSAHGQ PRSSTGGRQK SHQEHSADHS
RQSGTGHGRS PNESGAGRDR GSSVSQASDS EGQSEDSHRQ SGYASRHHQG STHGQSRDYS
RHSGSHQGHR DDGPHSHSAH GHSDSTARGR QGSSHGQSVD SSRHSDSHQG ESSAHGQSRS
STRGRQESHQ ERSADRSRHS GAGHAQSSFE SRAVRHRGPS VSRASDREGR SEDSHRQSGS
ASTHYHGSTH SQSRDSSRHS GSHQGHRANR PQSHPAHGHS DSTARGRQGS SHGQSVDTSR
HSGSHQRETS AHGQSRSSTR GRQESRQEHS ADHSRHSGDG RGQSSAESGE GRHRGSSVSQ
ASDSEGQSED SHRQSGSASG HHHGSNHGQS RDSSRHSRYH QGRRATAPNS HSTHGHSDST
AIGSQRPSYG QSVDSSRHSG SHQRETFTHG QSRSSTRGRQ ESRQKHSADH SRHSGTGHGQ
SPYESGVRRH RGSSVIQASD SEGQSEDSQT QSGYASRHHQ GSTHGQSRDN SRHSGSHQEH
RADGPESHSA HGHSDSTARG GQGSSHGQSV DSSSHSDSQQ GETSAHGQSR SKHSADRSRH
SGAGHAQSSF ESRAVRHRAP SVSQASDSEG QSEDSHRQSG YASTHYHGST HGQSRDSSRR
SGSHQGHRAD GPQSHPAHGH SDSTARGRQG SSHGQSADSS RHSGLSSXED SHRQSGYAST
HYHGSTHGQS RDSSRRSGSH QGHRADRPQS HPAHGHSDST ARARQGSSHG QPEDSSRHSG
SHQGETSTRA DHSRHSGARN AQSSFESGAG RHRGSSVSQA SDSEGQSEDS HRQSGFASTQ
YHGSTHGQSR DSSKHLGSHQ GHRANGPQSH SVHGHSDSTA RGRKGSSHGQ SVDSSRHSGS
HQGETSAHGQ SRSSTRGRQE TQQEHSADHS RHSVSGHGRS SFESGAGRHR GSSVGQASDS
KRQSEHSGIQ SGSGSGQQGR STYSQSRDSS RHSGSPQGLR ADAPQSHTAH GHSYSSAIGK
QGSSQGQSLD STRHSGSHHG ETSAHGESRS STRGKKESRQ EHSADTSRQS GTGRGRSTIE
SGAGRHGGSS VSQASDSEGQ SEDSHRQSGS ASGHHLESNH GQSRDSSRHS GYHQGHRTTA
PHSHSAHGHS DSTAIESQGP SYGQSAGETS THGQSRSSTR GRQESRQEHS ADRSRHSGAG
YAQSSLESGA VRHRGSSVSQ ASDSEGQSED SHRQSGYAST HYHGSTHGQA RDSSRHSGSH
QGHRADASQS HSAHGHSEST ARGRQGSSHG HSVDSSRHSS SHQGETSAHG QPRSSTGGRQ
KSHQEHSADH SRQSGTGHGR SPNESGAGRD RGSSVSQASD SEGQSEDSHR QSGYASRHHQ
GSTHGQSRDY SRHPGSHQGH RDDGPHSHSA HGHSDSTARG RQGSSHGQSV GESSAHGQSR
SSTRGRQESH QERSAERSRH SGAGHAQSSL ESGAVRHRGS SVSQASDSKG QSEDSHRQSG
YASGHQLESN HGQSRDSSRH SGYHRGHRAT APNAHSVHGH SDSTAKGSQG PSYRQSVDSS
RHSGSHQGET STHGQSRSST RGRQESHQEH SADRSRHSGA GHASGTEGQS EVSFGQSASN
HESSGFGSRN QPGSIHGQSG DSLRHSGSHS GQISTQRQSD STHVQQSQKA DHGQSDSNGR
INQGSSLCQ
//
