ID   G3UA52_LOXAF            Unreviewed;       474 AA.
AC   G3UA52;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Arylsulfatase family member J {ECO:0000313|Ensembl:ENSLAFP00000024710.1};
GN   Name=ARSJ {ECO:0000313|Ensembl:ENSLAFP00000024710.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000024710.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000024710.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024710.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000024710.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000024710.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3UA52; -.
DR   Ensembl; ENSLAFT00000028132.1; ENSLAFP00000024710.1; ENSLAFG00000010599.3.
DR   GeneTree; ENSGT00940000159954; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR   CDD; cd16029; 4-S; 1.
DR   Gene3D; 3.30.1120.10; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR047115; ARSB.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR   PANTHER; PTHR10342:SF69; ARYLSULFATASE J; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          3..259
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          402..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..463
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  54440 MW;  FF317E725E1336A8 CRC64;
     LLSRYQIHTG LQHSIIRPTQ PNCLPLDNAT LPQKLKEVGY STHMVGKWHL GFYRKECMPT
     KRGFDTFFGS LLGSGDYYTH YKCDSPGMCG YDLYENDRAA WDYDNGIYST QMYTQRVQQI
     LASHNPRKPI FLYIAYQAVH SPLQAPGRYF EHYRSIININ RRRYAAMLAC LDEAINNVTL
     ALETYGFYNN SIIIYSSDNG GQPTAGGSNW PLRGSKGTYW EGGIRAVGFV HSPLLKNKGT
     VCKELVHITD WYPTLITLAE GQIDEDVQLD GYDIWETISE GLRSPRVDIL HNIDPIYTKA
     KNGSWAAGYG IWNTAIQSAI RVQHWKLLTG NPGYSDWVPP QSFSNLGPNR WHNERITLST
     GKTIWLFNIT ADPYERVDLS NRYPGIVKKL LRRLSQFNKT AVPVRYPPKD PRSNPRLNGG
     VWGPWYKEEH KKKKPSKNKA GKKPKKRKTK KKKQPKKKKI TQKKLQSSLF NHYF
//