ID G3UBB1_LOXAF Unreviewed; 472 AA.
AC G3UBB1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=T-box transcription factor 22 {ECO:0000313|Ensembl:ENSLAFP00000025119.1};
GN Name=TBX22 {ECO:0000313|Ensembl:ENSLAFP00000025119.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025119.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000025119.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025119.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000025119.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025119.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; G3UBB1; -.
DR Ensembl; ENSLAFT00000037535.1; ENSLAFP00000025119.1; ENSLAFG00000001881.3.
DR GeneTree; ENSGT00940000161206; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 2.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF116; T-BOX TRANSCRIPTION FACTOR TBX22; 1.
DR Pfam; PF00907; T-box; 1.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 80..238
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 15..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 52927 MW; 01EADD8969628A96 CRC64;
MALSSRAHAF SVEALVGRPS KRKLQDPREE FQPNFQEKEG GKEERRCCAA GKRSEQSAQK
RPKAEPSATA FSGSVEERDA IQVELQGSEL WKRFHDIGTE MIITKAGRYV YHSSQWMVAG
NTDHRCIAPR LYVHPDSPCS GETWMRQIIS FDRVKLTNNE MDDKGHIILQ SMHKYKPRVH
VMEQDGGGDL SQIQSLPAGG VKTFSFKETE FTTVTAYQNQ QITKLKIDRN PFAKGFRDPG
RNRGILDGLL ETYPWRPSLT LDFKTFGADT QSGSSGSSPV TSSGGAPSPL NPLLSSPCSP
PMFHLPSCLG MPCPEAYPHI NLPLCYKICP TNFWQQQPLV LPVPERLSSI NSSQSLTPLM
LEIPILSSLG IHQFKKMVHL KTSVDSLYRH LILPVKMLYG LQAPGSIFQN SIAQKALACP
FYPSCGFYRY NFATPSRPYA ADHIKMNDQG QVSLRESKWN HAHWHPTINH CL
//
