ID G3UBF8_LOXAF Unreviewed; 126 AA.
AC G3UBF8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=C-X-C motif chemokine {ECO:0000256|RuleBase:RU361149};
GN Name=CXCL9 {ECO:0000313|EMBL:QQK85110.1,
GN ECO:0000313|Ensembl:ENSLAFP00000025166.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025166.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000025166.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025166.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QQK85110.1}
RP NUCLEOTIDE SEQUENCE.
RA de Waal C.R., Kleynhans L., Parsons S.D., Goosen W.J., Hausler G.,
RA Buss P.E., Warren R.M., van Helden P.D., Landolfi J.A., Miller M.A.,
RA Kerr T.J.;
RT "Development of a Cytokine Gene Expression Assay for the Relative
RT Quantification of the African Elephant (Loxodonta africana) Cell-Mediated
RT Immune Responses.";
RL Cytokine 141:1-8(2021).
RN [3] {ECO:0000313|Ensembl:ENSLAFP00000025166.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025166.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU361149}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665, ECO:0000256|RuleBase:RU361149}.
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DR EMBL; MT096349; QQK85110.1; -; mRNA.
DR EMBL; MT096350; QQK85111.1; -; mRNA.
DR RefSeq; XP_010592481.1; XM_010594179.1.
DR STRING; 9785.ENSLAFP00000025166; -.
DR Ensembl; ENSLAFT00000032938.1; ENSLAFP00000025166.1; ENSLAFG00000029889.1.
DR GeneID; 100660404; -.
DR KEGG; lav:100660404; -.
DR CTD; 4283; -.
DR eggNOG; ENOG502TDRN; Eukaryota.
DR GeneTree; ENSGT00940000161751; -.
DR HOGENOM; CLU_143902_2_2_1; -.
DR OMA; GKKYQKN; -.
DR OrthoDB; 4642028at2759; -.
DR TreeFam; TF333433; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR018048; Chemokine_CXC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF189; C-X-C MOTIF CHEMOKINE 9; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00436; INTERLEUKIN8.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis {ECO:0000256|RuleBase:RU361149};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU361149};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Secreted {ECO:0000256|RuleBase:RU361149};
KW Signal {ECO:0000256|RuleBase:RU361149}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU361149"
FT CHAIN 23..126
FT /note="C-X-C motif chemokine"
FT /evidence="ECO:0000256|RuleBase:RU361149"
FT /id="PRO_5041474086"
FT DOMAIN 28..89
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 126 AA; 14235 MW; F9B2FD345F25B243 CRC64;
MKKSGVPLVL GIIFLVLIEV QGIPTMKNGR CFCININQEK IQLQSLKDLQ QFAPSSSCGK
AEIIATLKNG DQTCLNPDLK DVKKLVKAWE KQTSQKKKQK KLGKRWKIKK GKTVGKFQRP
RQKKTA
//
