ID G3UDA3_LOXAF Unreviewed; 584 AA.
AC G3UDA3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Zinc finger protein 703 {ECO:0000313|Ensembl:ENSLAFP00000025811.1};
GN Name=ZNF703 {ECO:0000313|Ensembl:ENSLAFP00000025811.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000025811.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000025811.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025811.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000025811.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000025811.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Elbow/Noc family.
CC {ECO:0000256|ARBA:ARBA00010144}.
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DR AlphaFoldDB; G3UDA3; -.
DR Ensembl; ENSLAFT00000035992.1; ENSLAFP00000025811.1; ENSLAFG00000032676.1.
DR eggNOG; ENOG502QV57; Eukaryota.
DR GeneTree; ENSGT00390000014618; -.
DR HOGENOM; CLU_035082_1_0_1; -.
DR InParanoid; G3UDA3; -.
DR OMA; PSGIDHT; -.
DR TreeFam; TF324968; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR12522:SF2; ZINC FINGER PROTEIN 703; 1.
DR PANTHER; PTHR12522; ZINC-FINGER PROTEIN NOLZ1-RELATED; 1.
DR Pfam; PF12402; nlz1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 450..483
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 584 AA; 57935 MW; D09DACEAA35E9CAA CRC64;
GAGGGRHRAG WGGGAAAAAG RSSLPCEPTR PGSSPPPAVP AAVSLLPPAD PLRQANRLPI
RVLKMLSAHT GHLLHPEYLQ PLSSTPVSPI ELDAKKSPLA LLAQTCSQIG KPDPPPSSKL
NSVAAAANGL GTEKDPSRSA SGAASASAAL KQLGDSPAED KSSFKPYSKG SGGDSRKDGA
GDKAGFRVPS AACPPFPPHG APVSASSSSS SPGGSRGGSP HHSDCKNSGG GGSGELDKKD
QEPKPSPEPA AVSRGGGGEP GAHGGTEAVT SGRKSEPPSA LVGAGHVAPV SPYKPGHSVF
PLPPSSIGYH GSIVGAYAGY PSQFVPGLDP SKSGLVGGQL SGGLGLPPGK PPSSSPLTGA
SPPSFLQGLC RDPYCLGGYH SASHLGGSSC STCSAHDPTG PSLKAGGYPL VYPGHPLQPA
ALSSSAAQAA LPGHPLYTYG FMLQNEPLQH SCNWVAASGP CDKRFATSEE LLSHLRTHTA
LPGAEKLLAA YPGASGLGSA AAAAAAAASC HLHLPPPAAP GSPGSLSLRS PHTLGLSRYH
PYGKSHLSTA GGLAVPSLPT AGPYYSPYAL YGQRLASASA LGYQ
//
