ID G3UE18_LOXAF Unreviewed; 597 AA.
AC G3UE18;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=FMR1 autosomal homolog 1 {ECO:0000313|Ensembl:ENSLAFP00000026076.1};
GN Name=FXR1 {ECO:0000313|Ensembl:ENSLAFP00000026076.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026076.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026076.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026076.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026076.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026076.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}. Postsynapse
CC {ECO:0000256|ARBA:ARBA00034110}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR AlphaFoldDB; G3UE18; -.
DR Ensembl; ENSLAFT00000027464.1; ENSLAFP00000026076.1; ENSLAFG00000001908.3.
DR GeneTree; ENSGT00950000183189; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR CDD; cd22504; KH_I_FXR1_rpt1; 1.
DR CDD; cd22507; KH_I_FXR1_rpt2; 1.
DR CDD; cd22510; KH_I_FXR1_rpt3; 1.
DR CDD; cd20475; Tudor_Agenet_FXR1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR032172; FXR1_C1.
DR InterPro; IPR032177; FXR_C3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047494; KH_I_FXR1_rpt1.
DR InterPro; IPR047495; KH_I_FXR1_rpt2.
DR InterPro; IPR047496; KH_I_FXR1_rpt3.
DR InterPro; IPR047427; Tudor_Agenet_FXR1_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF6; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF16096; FXR_C1; 1.
DR Pfam; PF16097; FXR_C3; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 1..50
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 315..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 67047 MW; 74B52F5490A35C26 CRC64;
QVYSRANEQE PCGWWLAKVR MMKGEFYVIE YAACDATYNE IVTFERLRPV NQNKTVKKNT
FFKCTVDVPE DLREACANEN AHKDFKKAVG ACRIFYHPET TQLMILSASE ATVKRVNILS
DMHLRSIRTK LMLMSRNEEA TKHLECTKQL AAAFHEEFVV REDLMGLAIG THGSNIQQAR
KVPGVTAIEL DEDTGTFRIY GESADAVKKA RGFLEFVEDF IQVPRNLVGK VIGKNGKVIQ
EIVDKSGVVR VRIEGDNENK LPREDGMVPF VFVGTKESIG NVQVLLEYHI AYLKEVEQLR
MERLQIDEQL RQIGMGFRPS STRGPEKEKG YATDESTVSS VQGSRSYSGR GRGRRGPNYT
SGYVYGTNSE LSNPSETESE RKDELSDWSL AGEDDRESRH QRDSRRRPGG RGRSVSGGRG
RGGPRGGKSS ISSVLKDPDS NPYSLLDNTE SDQTADTDAS ESHHSTNRRR RSRRRRTDED
AVLMDGMTES DTASVNENGL DDSEKKPQRR NRSRRRRFRG QAEDRQPVTV ADYISRAESQ
SRQRNLPKHG PSEKAINGPT STSGDEISKL QRTPGEEKIS TLKEENPQAA AVLNGVS
//