ID   G3UEW5_LOXAF            Unreviewed;      1201 AA.
AC   G3UEW5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Tubulin tyrosine ligase like 4 {ECO:0000313|Ensembl:ENSLAFP00000026373.1};
GN   Name=TTLL4 {ECO:0000313|Ensembl:ENSLAFP00000026373.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026373.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000026373.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026373.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000026373.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026373.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   AlphaFoldDB; G3UEW5; -.
DR   STRING; 9785.ENSLAFP00000026373; -.
DR   Ensembl; ENSLAFT00000011721.3; ENSLAFP00000026373.1; ENSLAFG00000017623.4.
DR   eggNOG; KOG2156; Eukaryota.
DR   GeneTree; ENSGT00940000157916; -.
DR   InParanoid; G3UEW5; -.
DR   OMA; RNCMEVL; -.
DR   TreeFam; TF313087; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
DR   GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IEA:Ensembl.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0120222; P:regulation of blastocyst development; IEA:Ensembl.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   PANTHER; PTHR12241:SF162; TUBULIN MONOGLUTAMYLASE TTLL4; 1.
DR   PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR   Pfam; PF03133; TTL; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   REGION          13..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1123..1170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..460
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1201 AA;  133428 MW;  F4BA26EC89BE61BC CRC64;
     MASAGTEQYS IGLRRGNSFK QSGPSGTVHA LPLEKPSEGK GWSQAHQQVK PIWKLEKKHV
     GTLSTGLSPG LLGVPPQPAY FVCPSALCSS GTTAVIAGHS NSCYLNSLPD LFSSTLLYRC
     SNYRHKPYQQ LESFCLRSSP SEKRPFSLPE KSLPVSLTAS KATFSTVSPM ASSSTDPYLS
     SLGAAGENSS GRSLASAISG KIPSPLSSSS YKPMLNNNSF MRPNSTKVPL SQAPEGLKPV
     STPKIQIISW PHSGGTGDCT FQPIEHKVPR SNGTVLNDAT DHTTMSTPSS VDTFITSVAS
     PQYNLNNSAT RAEPHLSGLD DDSDSQAQTE EIRFTEAVRK LTARSFGKIP RQGFQFEQSC
     FVNRSFQWSL LNKDRQWEPP MVGQQFPQED DGADSRILPG ASDTLGLDST VFCTKRISIH
     LLASPASGLN HSPTCGSAID HPPLGGDRTL PPPPPPQPLG VADVATQLSS IHLGQPVKEP
     REDRQLDSPG RDIGSATDLQ PDQVEAEDVE EDLVDGLEDC CSHDENEEEE GDSECSSFSA
     VSPSESVAMI SRSCVEILTK PLSDHEKVVR PALIYSLFPN VPPTIYFGTR DERVEKLPWE
     QRKLLRWKMS TVTPNIVKQT IGRSHFKISK RNDDWLGCWG HHMKSASFRS IREHQKLNHF
     PGSFQIGRKD RLWRNLSRMQ SHFGKKEFSF FPQSFILPQD AKLLRKAWEN SSRQKWIVKP
     PASARGIGIQ VIHKWSQLPK RRPLLVQRYL HKPYLISGSK FDLRIYVYVT SYDPLRIYLF
     SDGLVRFASC KYSPSMKSLG NKFMHLTNYS VNKKNVEYQA NADETACQGH KWALKALWNY
     LSQKGINSDV IWEKIKDVVV KTIISSEPYV TSLLKMYVRR PYNCHELFGF DVMLDENLKP
     WVLEVNISPS LHSNSPLDIS IKGQMIRDLL NLAGFVLPSA EDILSSSSSS SSSTTSHISL
     TSTPRDKFRV ASEHVTAQKM KKAYYLTQKT PDQDFYASVL DVLTPDDVRV LVEMEDEFSR
     RGQFERIFPS RISTRYLRFF EQPRYFNILT TQWEQKYHSN KLKGVDLLRS WCYKGFHTGV
     ISDSAPVWSL PTSLLTVPKG DVMLNAFCKS EIGNLGKHSS SEGSLLLSED GATPKTKKTP
     VGLSPFPRKP NCSKDSEDTS KEPSLSTQML PLIKYSGQTS RLSASPISHS ASDSLLAAVS
     P
//