ID G3UEW6_LOXAF Unreviewed; 1128 AA.
AC G3UEW6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Ankyrin repeat and sterile alpha motif domain containing 1A {ECO:0000313|Ensembl:ENSLAFP00000026374.1};
GN Name=ANKS1A {ECO:0000313|Ensembl:ENSLAFP00000026374.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026374.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026374.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026374.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026374.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026374.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3UEW6; -.
DR STRING; 9785.ENSLAFP00000026374; -.
DR Ensembl; ENSLAFT00000036889.1; ENSLAFP00000026374.1; ENSLAFG00000011487.3.
DR eggNOG; KOG0507; Eukaryota.
DR GeneTree; ENSGT00940000155806; -.
DR HOGENOM; CLU_010379_0_0_1; -.
DR InParanoid; G3UEW6; -.
DR OMA; REGWSEC; -.
DR TreeFam; TF320582; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR CDD; cd01274; PTB_Anks; 1.
DR CDD; cd09499; SAM_AIDA1AB-like_repeat1; 1.
DR CDD; cd09500; SAM_AIDA1AB-like_repeat2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041880; SAM_ANKS1_repeat1.
DR InterPro; IPR041882; SAM_ANKS1_repeat2.
DR PANTHER; PTHR24174:SF4; ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 1A; 1.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00454; SAM; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 14..46
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 47..79
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 104..136
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 170..202
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 202..234
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 654..717
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 725..784
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 897..1028
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 265..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 124137 MW; 7FC4A569571CEE3C CRC64;
SIWRGPNVNC VDSTGYTPLH HAALNGHKDV VEVLLRNDAL TNVADCKGCY PLHLAAWKGD
AQIVRLLIHQ GPSHTKVNEQ NALEIKEFKK YGPFDRYINA KNNDNETALH CAAQYGHTEV
VKVLLEELTD PTMRNNKFET PLDLAALYGR LEVVKMLLNA HPNLLSCNTK KHTPLHLAAR
NGHKAVVQVL LDAGMDSNYQ TEKGSALHEA ALFGKTDVVQ ILLAAGIDVN IKDNRGLTAL
DTVRELPSQK SQQIAALIED HMTGKRSTKE IDKTPTPQLP LISNMDSLSQ RSQGNVEKAV
TELIIDFDTA AEEEGPYEAL YNAVSCYSLD SMASGRSSDR DSMTKEAAGV NAAGVRPRER
PPPPAKPPPD EEEEDRADKK YLPLTAPEIL AMRPRSQGSA ARNKDEHPYE LLLTAETKKL
VSVDGRPKDH RRSNSSRSQD SAEGQDGQVP EQFSGLLHGS SPVCEVGQDP FQLLSATGQG
NPEESPQQGA CHEASMQLEE SGVHTPGASQ PSTLDQSMRV GYPAGLPTAN SQSHPETLTH
TASPHPGGAE EEGDRSGARS RAPPTSKPKA ELKLSRSLSK SDSDLLTCSP TEDATMGSRS
ESLSSCSIGK KRLEKSPSFA SEWDEIEKIM SSIGEGIDFS QEQQKISGSR TLEQSVGEWL
ESIGLQQYES KLLLNGFDDV RFLGSNVMEE QDLREIGISD PQHRRKLLQA ARSLPKVKAL
GCDGNSPQSM PSWLDSLGLQ DYVHSFLSSG YSSIDTVKNL WELELVNVLK VHLLGHRKRI
IASLADRPYE EPPQKPPRFS QLRCQDLLSQ TSSPLSQNDS CTGRSADLLL PPADTGRRRH
DSLHDPGAHS RAERFRIQEE HHEAKLTLRP PSLAAPYAPV QSWQHQPEKL IFESCGYEAN
YLGSMLIKDL RGTESTQDAC AKMRKSTEHM KKIPTIILSI TYKGVKFIDA SNKNVIAEHE
IRNISCAAQD PEDLCTFAYI TKDLQTSHHY CHVFSTVDVN LTYEIILTLG QAFEVAYQLA
LQAQKSRPMG ASAAEMIETK SSKPVPKPRI GMRKSAVPQP PDSRCCYCHT CTTHRPSYLP
LPSVSSGVKL EPPDMDQDAQ SHASVSWVVD PKPDSKRSLS TKYETTIF
//
