ID G3UEX7_LOXAF Unreviewed; 1350 AA.
AC G3UEX7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 3 {ECO:0000313|Ensembl:ENSLAFP00000026385.1};
GN Name=MAPK8IP3 {ECO:0000313|Ensembl:ENSLAFP00000026385.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026385.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026385.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026385.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026385.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026385.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR STRING; 9785.ENSLAFP00000026385; -.
DR Ensembl; ENSLAFT00000026771.1; ENSLAFP00000026385.1; ENSLAFG00000028194.1.
DR eggNOG; KOG2077; Eukaryota.
DR GeneTree; ENSGT00940000153496; -.
DR InParanoid; G3UEX7; -.
DR OMA; MRNVSIX; -.
DR TreeFam; TF313096; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0030673; C:axolemma; IEA:Ensembl.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0008432; F:JUN kinase binding; IEA:Ensembl.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:Ensembl.
DR GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IEA:Ensembl.
DR GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IEA:Ensembl.
DR GO; GO:0099641; P:anterograde axonal protein transport; IEA:Ensembl.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0060425; P:lung morphogenesis; IEA:Ensembl.
DR GO; GO:2001224; P:positive regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0046328; P:regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:Ensembl.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 12..100
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 529..600
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 188..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 457..505
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 247..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1350 AA; 149277 MW; A5CBD51AEAAED0FD CRC64;
LMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE VVKELMPLVV
NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL RKQAEEKFIE FEDALEQEKK
DLQVQVEHYE FQTRQLELKA RNYADQISRL EERESEMKKE YNALHQRHTE MIQTYVEHIE
RAKLQQVGAN SQTEGGLPGR SPHQSWRKSR KERPTSLNVF PLTDGMVRAQ MGGKLTPAAD
HWHPSDRSQL PASSSYQCPH DEMSESGQSS AATTPSTTGT KSNTPTSSVP SAVVTPLNDS
LQPLGDYSSG TKNGKRAREK RNSRNMEVQV TQEMRNVSIG MGSSDEWSDV QDILDSTPEL
DMCQEPRLDR TSNSPTQGIV NKAFGINTDS LYHELSTAGS EVIGDVDEGA DLLGEGEVRD
DFFGMGKEVG NLLLENSQLL ETKNALNVVK NDLIAKVDQL SGEQEVLKGE LEAAKQAKTK
LEIRIKELEE ELRRVKSEAI TTRREPREEV EDVSSCLCTE LDNIPMAQRR RFTRVEMARV
LMERNQYKER LMELQEAVRW TEMIRASREH PSVQEKKKST IWQFFSRLFS SSSSPPPAKR
AYPSVNIHYK SPTTTGFSQR RGHTVCQISA GSRPLEFFPE DDCTSSARRE QKREQYRQVR
EHVRNDDGRL QACGWSLPAK YKQLSPNGSQ EDTRMKNVPV PVYCRPLVEK DPTMKLWCAA
GVNLSGWRPG DEELGNGTKP VPSHDPLTCN WEAEGEASSS HSSPEKKKAK ELHEMDATSS
RVWILTSTLT TSKVVIIDAN QPGTVVDQFT VCNAHVLCIS SIPAASDSDY PPGEIFLDVD
MNPEEPGADG VLAGITLVGC ATRCNVPRSN CSSRGDTPVL DKGQGEVAAV SNGQVNPAQS
TEEATEAMEA PEPGPSEPEA AAVRPGPLTE HVFTDPAPMP PPSTQPGSEN GLEAEASGAQ
PEPEPSAGHT GASSSAAPTM WLGAQNGWLY VHSAVANWKK CLHSIKLKDS VLSLVHVKGR
VLVALADGTL AIFHRGEDGQ WDLSNYHLMD LGHPHHSIRC MAVVYDRVWC GYKNKVHVIQ
PKTMQIEKSF DAHPRRESQV RQLAWIGDGV WVSIRLDSTL RLYHAHTHQH LQDVDIEPYV
SKMLGTGKLG FSFVRITALL IAGNRLWVGT GNGVVISIPL TETVVLHRGQ LLGLRANKMS
PTSGEGARSG GVIHVYGDDS SDKSASSFIP YCSMAQAQLC FHGHRDAVKF FVSVPGNVLA
TLNGSVLDSP SESPGVPATT LDTALDTAEG QKLKNVLVLS GGEGYIDFRI GDGEDDETEE
GGGDVSQVKP MLSKAERSHI IVWQVSYTTE
//
