ID G3UFA8_LOXAF Unreviewed; 1276 AA.
AC G3UFA8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSLAFP00000026516.1};
GN Name=ARHGEF10L {ECO:0000313|Ensembl:ENSLAFP00000026516.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026516.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026516.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026516.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026516.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026516.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3UFA8; -.
DR STRING; 9785.ENSLAFP00000026516; -.
DR Ensembl; ENSLAFT00000035351.1; ENSLAFP00000026516.1; ENSLAFG00000000409.3.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR InParanoid; G3UFA8; -.
DR OMA; HKCDCKM; -.
DR TreeFam; TF331430; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:Ensembl.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 313..500
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 480..513
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 30..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 139828 MW; F2762070780DF1FE CRC64;
MANSSSLLLI PSPGDQLVPR APGPSPEVED DPGEAFEFDD SDDEEDTSTG LAVPSVAAGK
ETDSPLVCFD SAPITDPDPA AAPPQTEVPA VVSNGDAVDT AFSGVRRSTW KGKSSHRIER
FTFPALEEDV IYDDVPCENL DAHQPGAERN LEDAHRDGSP RVADDLGWSS SEFESYSEDS
GEEAKLEAEP AKHRVSFQPK LSPDLTRLKE RYARTKRDIL ALKVGGRDMQ ELKHKYDCKM
TQLMKAAKSG TKDGLEKTRI AVMRKVSFLH RKDVLGDSEE EDMGLLEVSV SDIKPLAPEL
GPMPDGLSPQ QVVRRHILGS IVQSEGSYVE SLKRILQDYR NPLMEMEPKV LSVRKCQLVF
FRVKEILHCH SMFQIALSSR VAEWDSTEKI GDLFVASFSK SMVLDVYSDY VNNFTNAMSI
IKKACLTKPA FLEFLKRRQI CSPDRVTLYG LMVKPIQRFP QFILLLQDML KNTPRGHPDR
LSLQLALTEL ETLAEKLNEQ KRLADQVAEI QQLTKSVSDR SSLNKLLTSG QRQLLLCETL
TETVYGDRGQ LIKSKERRVF LLNDMLVCAN INFKPTNHRG QLEISSLVPL GPKYVVKWNT
ALPQVQVVEV GQEGGAYDKD NMLIQHAGAK KTSAAGQAQN KVYLGPPRLF QELQDLQKDL
AVVEQITLLI STLHGTYQNL NMTVAQDWCL ALQRLMRVKE EEIHSANKCR LRLLLPGKPD
KSGRPISFMV VFITPNPLSK ISWVNRLHLA KIGLREENQP GWLCPDEDKK SKAPFWCPIL
ACCVPAFCSR ALSLQLGALV HSPVNSPLLG FSAVSTSLPQ GYLWVGGGQE GAGGQVDIFS
LNRPSPRTVK SFPLAAPVLC MEYIPEPEEE GESRDESRTA ADPSAAVHPT ICLGLQDGSV
LVYGSVDTGT QCLATCRKPR PAACALSAHS PFHLFAGLQD GTLAAYPRTS GGVPWDLESP
PVCLTVGPGP VRTLLSLEDA VWASCGPRVT VLDATTLQTQ QSFEAHQDEA VSVTHMVKAG
SGVWMAFSSG SSIRLFHTET LEHLQEINIA TRTTFLLPGQ KHLCVTSLLI CQGLLWVGTD
QGVIVLLPVP RLEGIPKITG KGMVSLNGHC GPVAFLAVAT SILAPDILRS DQEEAEGSRA
EEDKPDGQPH EPAPAPAPES HVGRELTRKK GILLQYRLRS TAHLPGPLLS VREPGPTDGA
ALEHSEEDGS IYEMADDPDI WVRSRPCARD AHRKEICSMA IISGGQGYRN FGGGGRLAPC
GDTDSTLLIW QVPLTL
//
