ID G3UFT5_LOXAF Unreviewed; 1181 AA.
AC G3UFT5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN Name=WDR35 {ECO:0000313|Ensembl:ENSLAFP00000026693.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026693.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026693.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026693.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026693.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026693.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC required for retrograde ciliary transport and entry into cilia of G
CC protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR RefSeq; XP_003411952.1; XM_003411904.2.
DR AlphaFoldDB; G3UFT5; -.
DR STRING; 9785.ENSLAFP00000026693; -.
DR Ensembl; ENSLAFT00000034235.1; ENSLAFP00000026693.1; ENSLAFG00000014834.3.
DR GeneID; 100670900; -.
DR KEGG; lav:100670900; -.
DR CTD; 57539; -.
DR eggNOG; KOG2041; Eukaryota.
DR GeneTree; ENSGT00940000155745; -.
DR InParanoid; G3UFT5; -.
DR OMA; RLNCIAW; -.
DR OrthoDB; 148480at2759; -.
DR TreeFam; TF314076; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR PANTHER; PTHR12764:SF5; WD REPEAT-CONTAINING PROTEIN 55 HOMOLOG; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 130..191
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1181 AA; 133451 MW; 28CB4802C16D0B29 CRC64;
MFFYLSKKIA IPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LKLETQTDDA RLRGLAAPSN
LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLC HVAWSADSKV LLFGMANGEI
HIYDNQGNFM MKMKLSCLVN VTGAISIAGI HWYHGTEGYM EPDCPCLAIC FDNGRCQIMR
HENDPNPVLI DTGMYVVSIQ WNHVGTVLAV AGSQKAVAQD KDVNTVQFYT PFGEHLGTLK
VPGKQMSALS WEGSGLKIAL AVDSFIYFAN IRPDYKWGYC ANTVVYAYTR PDRPEYCVVF
WDTKNNEKYV KYVKSLISVT TCGDFCILAT KADENHPQEE NEMETFGATF VLVLCNSIGT
PMDPKYIDIV PLFVAMTKTH VIAASKEAFY IWQYRVAKKL TALEINQIVR SRKEGRERIY
HVDDTPSGSV DGVLDYSKAI QGTRDPICAI TASDKTLIVG RESGTIQRYS LPNVGLIQKY
SLNCQAYQLS LNCNSSRLAI IDISGVLTFF DLDARVTDST GQQVIGELLK LERKDVWDMK
WAKDNPDLFA MMEKTRMYVF RNLDPEEPIQ TSGYICNFED LEIKSVLLDE ILKNAEHPNK
DYIINFEIRS LRDSRALIEK VGIEDASQFI EDNPHPRLWR LLAEAALQKL DLQTAEQAFV
HCKDYQGIKF VKLLGNLQSE SMKQAEVAAY FGRFEEAERM YLDLDRRDLA IGLRLKLGDW
FRVLQLLKTG SGDADDSLLE QAHNAIGDYF ADRQKWLNAV QYYVQGRNQE RLAECYYMLE
DYEGLETLAN SLPENNKLLP EIAQMFVRVG MCEQAVMAFL KCNQPKAAVD TCVHLNQWNK
AVELAKNHSM KEIGSLLARY ASHLLEKNKT LDAIELYRKA NYFFDAAQLM FKIADEEARK
RTKPLRVKKL YVLSALLIEQ YHEQMKNAQQ GKVKGKSSEA TSALAGLLEE EVLSTAGRFT
DNAWRGAEAY HFFILAQRQL YEGYVDTALK TALHLRDYED IIPAVEIYSL LALCACAGRA
FGTCSKAFIK LESLDSLSSE QKQQYEDLAL EIFTKHTPKD NRKSELDSLL EGGEGKLPTC
VATGSPITEY QFWMCSVCKH CVLAQEISNY TFCPLCHSPV G
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