GenomeNet

Database: UniProt
Entry: G3UFT5_LOXAF
LinkDB: G3UFT5_LOXAF
Original site: G3UFT5_LOXAF 
ID   G3UFT5_LOXAF            Unreviewed;      1181 AA.
AC   G3UFT5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN   Name=WDR35 {ECO:0000313|Ensembl:ENSLAFP00000026693.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026693.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000026693.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026693.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000026693.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026693.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC       required for retrograde ciliary transport and entry into cilia of G
CC       protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC       ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR   RefSeq; XP_003411952.1; XM_003411904.2.
DR   AlphaFoldDB; G3UFT5; -.
DR   STRING; 9785.ENSLAFP00000026693; -.
DR   Ensembl; ENSLAFT00000034235.1; ENSLAFP00000026693.1; ENSLAFG00000014834.3.
DR   GeneID; 100670900; -.
DR   KEGG; lav:100670900; -.
DR   CTD; 57539; -.
DR   eggNOG; KOG2041; Eukaryota.
DR   GeneTree; ENSGT00940000155745; -.
DR   InParanoid; G3UFT5; -.
DR   OMA; RLNCIAW; -.
DR   OrthoDB; 148480at2759; -.
DR   TreeFam; TF314076; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR   GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR   Gene3D; 1.25.40.470; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR039857; Ift122/121.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR017233; WDR35.
DR   PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR   PANTHER; PTHR12764:SF5; WD REPEAT-CONTAINING PROTEIN 55 HOMOLOG; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW   Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW   Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW   Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   REPEAT          67..98
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          130..191
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
SQ   SEQUENCE   1181 AA;  133451 MW;  28CB4802C16D0B29 CRC64;
     MFFYLSKKIA IPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LKLETQTDDA RLRGLAAPSN
     LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
     MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLC HVAWSADSKV LLFGMANGEI
     HIYDNQGNFM MKMKLSCLVN VTGAISIAGI HWYHGTEGYM EPDCPCLAIC FDNGRCQIMR
     HENDPNPVLI DTGMYVVSIQ WNHVGTVLAV AGSQKAVAQD KDVNTVQFYT PFGEHLGTLK
     VPGKQMSALS WEGSGLKIAL AVDSFIYFAN IRPDYKWGYC ANTVVYAYTR PDRPEYCVVF
     WDTKNNEKYV KYVKSLISVT TCGDFCILAT KADENHPQEE NEMETFGATF VLVLCNSIGT
     PMDPKYIDIV PLFVAMTKTH VIAASKEAFY IWQYRVAKKL TALEINQIVR SRKEGRERIY
     HVDDTPSGSV DGVLDYSKAI QGTRDPICAI TASDKTLIVG RESGTIQRYS LPNVGLIQKY
     SLNCQAYQLS LNCNSSRLAI IDISGVLTFF DLDARVTDST GQQVIGELLK LERKDVWDMK
     WAKDNPDLFA MMEKTRMYVF RNLDPEEPIQ TSGYICNFED LEIKSVLLDE ILKNAEHPNK
     DYIINFEIRS LRDSRALIEK VGIEDASQFI EDNPHPRLWR LLAEAALQKL DLQTAEQAFV
     HCKDYQGIKF VKLLGNLQSE SMKQAEVAAY FGRFEEAERM YLDLDRRDLA IGLRLKLGDW
     FRVLQLLKTG SGDADDSLLE QAHNAIGDYF ADRQKWLNAV QYYVQGRNQE RLAECYYMLE
     DYEGLETLAN SLPENNKLLP EIAQMFVRVG MCEQAVMAFL KCNQPKAAVD TCVHLNQWNK
     AVELAKNHSM KEIGSLLARY ASHLLEKNKT LDAIELYRKA NYFFDAAQLM FKIADEEARK
     RTKPLRVKKL YVLSALLIEQ YHEQMKNAQQ GKVKGKSSEA TSALAGLLEE EVLSTAGRFT
     DNAWRGAEAY HFFILAQRQL YEGYVDTALK TALHLRDYED IIPAVEIYSL LALCACAGRA
     FGTCSKAFIK LESLDSLSSE QKQQYEDLAL EIFTKHTPKD NRKSELDSLL EGGEGKLPTC
     VATGSPITEY QFWMCSVCKH CVLAQEISNY TFCPLCHSPV G
//
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