ID G3UG21_LOXAF Unreviewed; 1034 AA.
AC G3UG21;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Semaphorin 6A {ECO:0000313|Ensembl:ENSLAFP00000026779.1};
GN Name=SEMA6A {ECO:0000313|Ensembl:ENSLAFP00000026779.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000026779.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000026779.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026779.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000026779.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000026779.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; G3UG21; -.
DR Ensembl; ENSLAFT00000031211.1; ENSLAFP00000026779.1; ENSLAFG00000004387.3.
DR GeneTree; ENSGT00940000156565; -.
DR HOGENOM; CLU_009051_2_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11266; Sema_6A; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF12; SEMAPHORIN-6A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1034
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003456699"
FT TRANSMEM 649..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..516
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 760..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 115090 MW; 641D37DD4033CE56 CRC64;
MRSEALLLYF TLLHFAGAGF PEDSEPISIS HGNYTKQYPV FVGHKPGRNT TQRHRLDIQM
IMIMNRTLYV AARYRDHIYA VDIDTSHTEE IYCSRKLTWK SRQADVDTCR MKGKHKDECH
NFIKVLLKKN DDTLFVCGTN AFNPSCRNYK MDTLDPFGDE FSGMARCPYD AKHANVALFA
DGKLYSATVT DFLAIDAVIY RSLGDSPTLR TVKHDSKWLK EPYFVQAVDY GDYIYFFFRE
IAVEYNTMGK VVFPRVAQVC KNDMGGSQRV LEKQWTSFLK ARLNCSVPGD SHFYFNILHA
VTDVIRINGR DVVLATFSTP YNSIPGSAVC AYDMLDIANV FTGRFKEQKS PDSTWTPVPD
ERVPKPRPGC CAGSSSLEKY ATSNEFPDDT LNFIKTHPLM DEAVPSIINR PWFLRTMVRY
RLTKIAVDTA AGPYQNHTVV FLGSEKGIVL KFLARIGNSG FLNDSLFLEE MSVYNPEKIR
CSYDGVEDKR IMGMQLDKAS SSLYVAFSTC VIKVPLGRCE RHGKCKKTCI ASRDPYCGWV
KEGGSCTHLS PSSRLTFEQD IERGNTDGLG DCHNSFVALN GHSSSLLPST TTSDSTAQEG
YESRGGMLDW KDLLDSPDST DPLGAVSSHN HQDKKGVIRE SYLKGHDQLV PVTLLAIAVI
LAFVMGAVFS GIIVYCVCDH RRKDVTVVQR KEKELTHSRR GSMSSVTKLS GLFGDTQSKD
PKPEAILTPL MHNGKLATPS NTAKVLIKAD QHHLDLAALP TPESTPTLQQ KRKPSRGSRE
WERNQNLINA CTKDMPPMAS PVIPTDLPLR ASPSHIPSVV VLPITQQSYQ HEYVDQPKMS
EVAQMVLEDQ AATLEYKTIK EHLSSKSPNH GVNLVENLDN LPPKVPQREA SLGPPGSSLS
QNGLSKRLEM HHSSSYGVDY KRSYPTNSLT RSHQATTLKR NNTNSSNSSH LSRNQSFGRG
DNPPPAPQRV DSIQVHSSQP SGQAVTVSRQ PSLNAYNSLT RSGLKRTPSL KPDVPPKPSF
APLSTSMKPN DACT
//
