ID G3UGV3_LOXAF Unreviewed; 683 AA.
AC G3UGV3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Ribosome biogenesis protein BOP1 {ECO:0000256|HAMAP-Rule:MF_03027};
DE AltName: Full=Block of proliferation 1 protein {ECO:0000256|HAMAP-Rule:MF_03027};
GN Name=BOP1 {ECO:0000256|HAMAP-Rule:MF_03027,
GN ECO:0000313|Ensembl:ENSLAFP00000027061.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000027061.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000027061.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027061.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000027061.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027061.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and
CC WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
CC {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000256|HAMAP-Rule:MF_03027}.
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DR AlphaFoldDB; G3UGV3; -.
DR Ensembl; ENSLAFT00000034948.1; ENSLAFP00000027061.1; ENSLAFG00000000686.3.
DR GeneTree; ENSGT00390000018422; -.
DR HOGENOM; CLU_011390_1_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03027};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03027};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03027};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 82..338
FT /note="BOP1 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01035"
FT REPEAT 345..386
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 596..626
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 75818 MW; 38B3B614DD59C7E7 CRC64;
DSGLSNSEES VFSGLEDSGS DNDSEDGANS DEGHVGTGRT IEKQSQAGTP SPRTEATDDE
YAEDSSDEED IRTVGNVPLE WYADFPHVGY DLDGRRIYKP LRTRDELDQF LDKMDDPNYW
RTVQDRATGR EVQLTDEQVA LVRRLQRGQF GDVSFDPYEP AVDFSADLMI HPVTNRPADK
RSFIPSLVEK EKVSRMVHAI KMGWIQPRRP RDPAPSYYDL WAQEDPNAVL GRHKMHVPAP
KLALPGHAES YNPPPEYLPS EEERLAWERQ EPGEGKLDFL PHKFPSLRAV PAYSRFIQER
FERCLDLYLC PRQRKMRVNV DPEDSPQLPR PRDLQPFPTC QALVYRGHSD LVRCLSVSPG
GQWLASGSDD GSVRLWEVAS ARCMKTVPVG AVVKSITWNP NPAVCLVAVA VEDAVLLLNP
ALGDRLVADG TDQLLSAFCP PEEPALQPAQ WLEAAEEERQ GGLRLRICHG KPSDTGGLGH
GRGDYLAVVL ATQGRRVLIH QLSPAPASPE PFSARSHGQG CRRVALPPPP RAFPAAQASA
STHLLRQELT KKLMPNCKWV SSLAVHPAGD NIICGSYDSK LVWFDLDLST RPYKVLRHHK
KALRAVAFHP RYPLFASGSD DGSVIVCHGM VYNDLLQNPL LVPVKVLKGH VLTRGLGVLD
VAFHPTQPWL FSSGADGTLR LFT
//