ID G3UIF7_LOXAF Unreviewed; 722 AA.
AC G3UIF7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Transmembrane protein 63A {ECO:0000313|Ensembl:ENSLAFP00000027615.1};
GN Name=TMEM63A {ECO:0000313|Ensembl:ENSLAFP00000027615.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000027615.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000027615.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027615.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000027615.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027615.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR AlphaFoldDB; G3UIF7; -.
DR Ensembl; ENSLAFT00000030596.1; ENSLAFP00000027615.1; ENSLAFG00000017739.3.
DR GeneTree; ENSGT00940000159576; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR13018:SF24; CSC1-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..201
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 219..402
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 414..684
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 722 AA; 82882 MW; 00FF07DFC5E54297 CRC64;
YCYNSAKNST VLQGVNFGGI PIVLLIDVSC FLTIILVFSF IRRRFWDYGR VALVSSEAER
RSRRQRVGLG LISSCLHHFS ESRFQRLSSS SSSGQQDFEN ELGCCAWLTA IFYLTDDQIL
EWCGEDAIHY LSFQRHIIGL LVVVSFLSLC VILPVNLSGN LLDKDPYSFG RTTIANLQTD
TNLLWLHTVF AVIYLILTVG FMRHHTQSIR YKAESLVRRT LFITGLPRDA NKEKVESHFR
DAYPTCQVVE VQLCYNVAKL IYLCKERKKT EKSLTYYTNL QVKTGQRVLI NPKTCGQFCC
CEVPGCEGQE DAISYYTHLK DGLMEKIAEE ECRVQYQPLG MAFVTFQEKS MATHILKDFN
ACKCQGLQCK GEPQPSSHSR ELCTSKWTVT FATYPEDICW KNLSIQGLRW WLQWLGINFT
LFLGLFFLTT PSIILSTIDK FNVTKPIHAL NNPVISQFFP TLLLWSFSAL LPTIVYYSTL
LESHWTKSGE NWIMMTKVYI FLIFMVLILP SLGLTSLDFF FRWLFDKTFS EASVRLECVF
LPDQGAFFVN YVIASAFIGN AMELLRLPGL ILYTFRMIMA KTAADRRNVK QNQAFEYEFG
AMYAWMLCVF TVIVAYSITC PIIAPFGLVY ILLKHMVDRH NLYFIYLPAK LEKKIHFAAV
NQALAAPILC LFWLFFFSFL RLGLKAPATL FTFLVVLLTI LVCLAYTCFG CFKHLSPLNY
KV
//
