ID G3UIM7_LOXAF Unreviewed; 4588 AA.
AC G3UIM7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=FAT atypical cadherin 3 {ECO:0000313|Ensembl:ENSLAFP00000027685.1};
GN Name=FAT3 {ECO:0000313|Ensembl:ENSLAFP00000027685.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000027685.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000027685.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027685.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000027685.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027685.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9785.ENSLAFP00000027685; -.
DR Ensembl; ENSLAFT00000031636.1; ENSLAFP00000027685.1; ENSLAFG00000017223.3.
DR eggNOG; KOG1219; Eukaryota.
DR GeneTree; ENSGT00940000154981; -.
DR InParanoid; G3UIM7; -.
DR OMA; HFLMDSN; -.
DR TreeFam; TF316403; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 27.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 34.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 14.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..4588
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003456805"
FT TRANSMEM 4154..4174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..157
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 158..265
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 376..471
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 472..577
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 586..680
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 726..830
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 831..935
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 936..1042
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1050..1152
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1148..1253
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1254..1358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1362..1459
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1460..1565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1566..1768
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1769..1882
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1898..1981
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1982..2083
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2084..2185
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2186..2286
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2287..2393
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2394..2495
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2496..2599
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2600..2707
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2708..2813
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2814..2923
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2924..3028
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3029..3130
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3131..3235
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3236..3340
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3341..3445
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3446..3550
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3561..3652
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3794..3832
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3834..4017
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4020..4057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4059..4095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4097..4133
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4327..4346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 4047..4056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4085..4094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4123..4132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4588 AA; 505458 MW; 39E6F1D240699957 CRC64;
MDIIMGYCVG TRPPPCLILL LLKLLATVSQ GLPRTGPLGF HFTHSIYNAT VYENSAARTY
VNSQSRMGIT LIDLSWDIKY RIVSGDEEGF FKAEEVIIAD FCFLRIRTKG GNSAILNREI
QDNYLLIVKG SVRGEDLEAW TKVNIQVLDM NDLRPLFSPT TYSVTIAEST PLRTSVAQVT
ATDADIGSNG EFYYYFKSKV DLFSVHPTSG VISLSGRLNY DEKSRYDLEI LAVDRGMKLY
GNNGVSSTAK LYVHIERINE HAPTIHVVTH VPFSLDKEPT YAVVTVDDLD EGANGEIETL
SIVAGDPLDQ FFLAKEGKWL NEYKIQERKQ IDWQSFPYGY NLTLQAKDKG SPQKFSALKI
VHIANPQRDA VPVRFEKEVY EVSISEFSPP GVVVAIVKLS PEPLDVEYKL SPGEDAEYFK
INPRSGLIVT AQPLNTIKKE VYKLGVTNRE GDLKAQVTIG IEDANDHTPE FQQPLYEAFV
NESVPVGTSV LTVSASDKDK GENGYITYSI ASLNLLPFAI NQFTGVISTT EELDFESSPE
TYRFIVRASD WGSPYRHESE VNVTIRIGNV NDNSPLFEKV ACQGVISYDF PVGGHITAVS
AIDIDELELV KYKIISGNEL GFFYLNPDSG VLQLKKSLMN SGIKNGNFGL RITATDGENF
ADPMSVNISV LHGKVSSKSF SCRETRVAQK LAEKLLIKAK ANGKLNLEDG FLDFYSINRQ
GPHFDKSFPS DVAVKEDLPV GANILKIKAY DADSGFNGKV LFTISDGNTD SCFNIDMETG
QLKVLMPMDR EQTDLYLLNI TIYDLGNPQK SSWRLLTINV EDANDNNPIF LQDSYSVNIL
ESSSIGTEII QVEARDKDLG SNGEVTYSVL TDTQQFGINS STGIVYVADQ LDRESQSNYS
LKIEARDKSE SGQQLFSVVT LKVFLDDVND CSPAFIPSSY SVKVLEDLPV GTVIAWLETH
DPDLGLGGQV RYSLVNDYNG RFEIDKASGA IRLSKELDYE KQQFYNLTVR AKDKGRPVSL
SSVSFVEVEV VDVNENLHTP YFPDFAVVGS VKENSRIGTS VLQVTAHDED SGRDGEIQYS
IRDGSGLGRF NIDDESGVIT TADILDRETM GSYWLTVYAT DRGVVPLYST IEVYIEIEDV
NDNAPLTSEP IFYPVVMENS PKDVSVIQIQ AEDPDSSSNE KLTYRITSGN PQNFFAINIK
TGLIMTTSRK LDREQQAEHF LEVTVTDGGS SPKQSTIWVV VQVLDENDNK PQFPEKVYQI
KLPERDRKKR GEPIYRAFAF DRDEGPNAEI SYSIVDGNDD GKFFIDPKTG MVSSRKQFTA
GSYDILTIKA VDNGRPQKSS TARLHIEWIK KPPPSPIPLT FDEPFYNFTV MENDRVTEIV
GVVSVQPANT PLWFDIVGGN FDSSFDAEKG VGTIVIAKPL DAEQRSFYNM SVEVTDGTNV
AVTQVFIKVL DNNDNGPEFS QPNYDVTISE DVLPDTEILQ IEATDRDEKH KLSYTIHSSI
DSVSMRKFRI DPSTGILYTA ERLDHEAQDK HILNIMVRDQ EFPYRRNLAR VIVNVEDAND
HSPYFTSPLY EASVFESAAL GSAVLQVTAL DKDKGENAEL IYTIEAGNTG NTFKIEPVLG
IITVSKEPDL TTMSQFVLSV KVTDQGSPPM SATAIVRISV TMSDNSHPKF THKDYQAEVN
ENVDIGTSVI LISAISQSTL IYEVKDGNVD GMFTINPYSG VITTRKALDY ERSSSYQLII
QATNMAGMAS NATVNIQVVD ENDNAPVFLF SQYSGSLSEA APVNSIVRSA DNSPLVIRAT
DADSSRNALL VYQIVESTAK KFFTVDSNTG AIRTIANLDH ETIAHFHFHV HVRDSGSPQL
TAESPVEVNI EVTDVNDNPP VFTQAVFETV LLLPTYVGVE VLRVSATDPD SEVPPELTYS
LKEGSLDQFF IDSISGVLTI KNNNLSKDHY MLIVTVSDGK FHSTAMINIM VKEAMDSGLH
FTQSVYSTSI SENSTNITKV AIVNAVGNRL NEPLKYSILN PGNKFKIKST SGVIQTTGVP
FDREEQELYE LVVEASRELD HLRVARVVVR VNIEDINDNS PVFVGLPYYA AVQVDAEPGT
LIYQVTAIDK DKGANGEVTY ILQDDYGHFE INPNSGNVIL KEAFNSDLSN IEYGVTILAR
DGGKPSLSAS VELPITIVNK AMPVFDKPFY TASINEDIRM DTPILSINAT SPEGQGIVYI
IIDGDPYKQF NIDFDTGVLK VASPLDFEIT PVYKLTVRAS DALTGARAEV TVDLLVNDVN
DNPPIFDEPT YNTTLSEASL IGTPVLQVVS TDADSENNKM VHYQIVQDTY NSTDYFHIDS
ASGLILTARM LDHELVQHCT LKVRATDSGF PSLSSEVLVH IYISDINDNP PIFNQLIYES
YVSELAPRGH FVTRVQASDA DSSDFDRLEY SILSGNDRTS FLMDSKSGVI TLSNHRKQRM
EPLYSLNVSV SDGLFTSTAQ VHIRVLGANL YSPAFSQSMY VAEVRENAAA GTKVIHVRAT
DGDPGTYGQI SYAIINDFAK DRFLIDSNGQ VLTTERLDRE NPLEGDISIF LRALDGGGRT
TFCTVRVIVV DENDNAPQFM TVEYRASVRA DVGRGHLVTQ VQAMDPDDGA NSRITYSLYS
EASVSVADLL EIDPDNGWMV TKGNFNQLKN TVLSFFVKAV DGGIPVKHSL IPVYIHVLPP
ETFLPSFTQS QYSFTIAEDT AIGSTVDTLR ILPSQNVRFS TVNGERPENN KGGIFVIEQE
TGTIKLDKRL DHEISPAFHF KVAATIPLDK VDIVFTVDVD IKVLDLNDNK PVFDTSSYET
IIMEGMPVGT KLTQVRALDM DWGANGQVTY SLQSDSQPEK VMEAFNIDTN TGWISTLKDL
DHETDPTFTF SVVASDLGEA FSLSSTALIS VRVTDINDNA PVFAHEVYRG NVKESDPPGE
VVAVLSTWDR DTSDINRQVS YHITGGNPRG RFALGLVQNE WKVYVKRPLD REEQDIYFLN
ITATDGLFVT QAMVEVTVSD VNDNSPVCDQ VAYTALFPED IPSNKIILKV SAKDADIGSN
GDIRYSLYGS GNNEFFLDPE SGELKTLALL DRERVPVYSL IARATDGGGR FCQSDVHLIL
EDVNDNPPVF SSDHYNACVY ENTATKALLT RVQAVDPDVG INRKVVYSLA DSADGFFSID
GLSGIIILEQ PLDRELQSSY SISVQATDQS PGQALSSFTT VTITVLDIND NPPVFERRDY
LVTVPEDTSP GTQVLTVFAT SKDIGTNAEI TYLIRSGNEQ GKFRINPKTG GISVSEVLDY
ELCKKFYLVV EAKDGGIPAL SAVATVSINL TDVNDNPPKF SQDIYSAVIS EDALVGDSVI
LLIAEDVDSQ PNGQIQFSIV NGDRDNEFAV EPVLGLVKVK KKLDRERVSG YSLLVQAVDS
GIPAMSSTAT VNIDISDVND NGPVFTPANY TAVIQENKPV GTSILQLVVT DRDSFHNGPP
FSFSILSGNE EEEFVLDPHG VLRSAVVFRH TESPEYVLCV QAKDSGKPQQ VSHSYIRVRV
IEESIHKPTA IPLEIFIVTM EDDFPGGVIG KIHATDQDVY DVLTFALKSE QKSLFKVNSH
DGKIIALGGL DSGKYVLNVS VSDGRFQVPI DVVVHVEQLV HEMLQNTVTI RFENVSPEDF
VGLHMLGFRR TLRNAVLSQK QDSLHIVSIQ PVAGTNQLDM LFAVEMHSSE FYKPAYLIQK
LSNARRHLEN VMRISAILEK NCSGLDCQEQ HCEQGLSLDS HALMTYSTAR ISFVCPRFYR
NVRCTCNGGL CPGSNDPCVE KPCPGDMQCV GYEASRRPFL CQCPPGKLGE CSGHTSLSFA
GNSYIKYRLS ENSKEEDFKL ALRLRTLQSN GIIMYTRANP CIILKIADGK LWFQLDCGSG
PGILGISGRA VNDGSWHSVF LELNRNFTSL SLDDSYVERR RAPLYFQTLS TESTIYFGAL
VQADNIRSLT DTRVTQVLSG FQGCLDSVVL NNNELLLQNK RSSFAEVVGL TELKLGCVLY
PDACERSPCQ HGGSCAGLPS GGYQCTCLSQ FTGRNCESEI TACFPNPCRN GGSCDPIGNT
FICNCKDGLT GVRCEEDINE CEREECENGG SCVNVFGSFL CNCTPGYVGQ HCGLRPVVVP
NIQAGHSYVG KEELIGIAVV LFVIFILIIL FIVFRKKVFR KNYSRNNITL VQDPATAALL
NKSNGIQFRN LRGGGDGRNV YQEVGPPQVP VRPMAYTPCF QSDSRSNLDK IVDGLGGEHQ
EMTTFHPESP RILTARRGVV VCSVAPNLPS VSPCRSDCDS IRKSGWDAGT ENKGVDDSGE
VTCFAGSNKG SNSEVQSLSS FQSDSGDDNA SIVTVIQLVN NVVDNIENEV SVMDQGQNYN
RAYHWDTSDW MPGARLSDIE EVPNYENQDG GSAHQGSTRE LESDYYLGGY DIDSEYPPPH
EEEFLSQDQL PPPLPEDFPD HYEALPPSQP VSLASTLSPD CRRRPQFHPS QYLPPHPFPN
ETDLVGLPAG CEFSTFAVSM NQGTEATGPA DSVSLPLHNS RGTSSSDVSA TCGFDDSEVA
MSDYESVGEL SLASLHIPFI ETQHQTQV
//