ID G3UJN7_LOXAF Unreviewed; 994 AA.
AC G3UJN7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX36 {ECO:0000313|Ensembl:ENSLAFP00000028046.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028046.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028046.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028046.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028046.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028046.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR AlphaFoldDB; G3UJN7; -.
DR Ensembl; ENSLAFT00000033499.1; ENSLAFP00000028046.1; ENSLAFG00000015342.3.
DR GeneTree; ENSGT00940000156903; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17981; DEXHc_DHX36; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA_RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 203..373
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 463..633
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 113313 MW; 75BCB521CD4A034A CRC64;
MSSDYSQSWG RDGCPRSSGG GFGGGRGGGH GGSRGRGRHP GHLKGRQIGL WYARLQGQKN
KEAERQERAV VHMDEHREER IVQLLNSVQA KNDKDSEAQI SWFAPEDHGQ NTEVPAENKP
SSEKKLEDQE KKLINQEKKP FRSRDRSYMD RDSEYLLQEN EPDITLDRQL LEDLQRKKTE
PRYIEMQHFR EKLPSHGMQK ELVSLIANHQ VTVISGETGC GKTTQVTQFI LDDYIKQGKG
SACRIVCTQP RRISAISVAE RVAAERAEPC GNGNSTGYQI RLQSRLPRKQ GSILYCTTGI
ILQWLQSDPH LSSVSHMVLD EIHERNLQSD VLMTVIKDLL TSRPDLKVIL MSATLNAEKF
SEYFGHCPMI HIPGFTFPVV EYLLEDIIEK IRYVPEQKEP RSQFRRGFMQ GRVSRQEKEG
KEAIYEERWP DYVRELRGRY SARTVDVLEM MDDDKVDLNL IAALIRHIVL EEEDGAILVF
LPGWDNISSL HDLLMSQVMF KSDKFLIIPL HSLMPTVNQT QVFKKTPPGV RKIVIATNIA
ETSITIDDVV YVIDGGKIKE THFDTQNNIS TMSAEWVSKA NAKQRKGRAG RVQPGHCYHL
YNGLRASLLD DYQLPEILRT PLEELCLQIK ILRLGGIAYF LRRLMDPPSN EAVLLSIKHL
IELNALDKQE ELTPLGVHLA RLPVEPHIGK MILFGALFCC LDPVLTIAAS LSFKDPFVIP
LGKEKIADAR RKELAKGSRS DHLTVVNAFK GWEEARRRGF RYEKDYCWEY FLSSNTLQML
HSMKAQFAEH LLGAGFVGGR NPKDPDSNIN SDNEKIIKAV ICAGLYPKVA KIRPNLGKKR
KMVKVYTKSD GLVAIHPKSV NVEQTDFHYN WLIYHLKMRT SSIYLYDCTE VSPYCLLFFG
GDISIQKDDD QETIAVDEWI VFQSPARIAH LVKELRKELD VLLQEKIESP HPVDWNDTKC
RDCAVLSAII DLIKTQEKAM PRNFPPRYQD GCYS
//
