ID G3UK80_LOXAF Unreviewed; 3053 AA.
AC G3UK80;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=CUB and Sushi multiple domains 2 {ECO:0000313|Ensembl:ENSLAFP00000028239.1};
GN Name=CSMD2 {ECO:0000313|Ensembl:ENSLAFP00000028239.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028239.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028239.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028239.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028239.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028239.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSLAFT00000034689.1; ENSLAFP00000028239.1; ENSLAFG00000002950.3.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000159768; -.
DR InParanoid; G3UK80; -.
DR OMA; TECLDTG; -.
DR TreeFam; TF316872; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 26.
DR CDD; cd00041; CUB; 11.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 26.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 11.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF6; CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 11.
DR Pfam; PF00084; Sushi; 26.
DR SMART; SM00032; CCP; 26.
DR SMART; SM00042; CUB; 11.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 26.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 11.
DR PROSITE; PS01180; CUB; 11.
DR PROSITE; PS50923; SUSHI; 26.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2977..2998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..62
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 64..172
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 175..236
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 238..346
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 351..408
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 410..520
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 523..582
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 584..692
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 695..755
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 757..866
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 869..929
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 931..1039
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1042..1103
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1105..1213
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1219..1280
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1282..1390
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1393..1452
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1454..1562
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1565..1624
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1626..1737
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1736..1797
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1799..1910
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1910..1972
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1973..2034
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2035..2099
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2100..2157
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2162..2219
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2220..2277
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2278..2340
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2341..2398
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2402..2459
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2460..2518
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2519..2578
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2579..2636
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2637..2694
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2701..2759
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2760..2819
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 33..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 379..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 757..784
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2128..2155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2190..2217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2248..2275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2311..2338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2369..2396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2430..2457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2489..2516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2607..2634
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2665..2692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2730..2757
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3053 AA; 332261 MW; 4699056AACFC1BA3 CRC64;
EIEQGSCGDP GIPAYGRREG SRFRHGDTLK FECQPAFELV GQKAITCQKN NQWSAKKPGC
VFSCFFNFTS PSGIVLSPNY PEDYGNHLHC VWLILARPES RIHLAFNDID VEPQFDFLVI
KDGATAEAPV LGTFSGNQLP SSITSSGHVA RLEFQTDHST GKRGFNITFT TFRHNECPDP
GVPVNGKRFG DSLQLGSSIS FLCDEGFLGT QGSETITCIL KEGSVVWNSA VLRCEAPCGG
HLTSPSGTIL SPGWPGFYKD ALSCAWVIEA QPGYPIKITF DRFKTEVNYD TLEVRDGRTY
SAPLIGVYHG TQVPQFLIST SNYLYLLFST DKSHSDIGFQ LRYETITLQS DHCLDPGIPV
NGQRHGNDFY VGALVTFSCD SGYTLSDGEP LECEPNFQWS RALPSCEALC GGFIQGSSGT
ILSPGFPDFY PNNLNCTWII ETSHGKGVFF TFHTFHLESG HDYLLITENG SFTQPLKQLT
GSRLPAPISA GLYGNFTAQV RFISDFSMSY EGFNITFSEY DLEPCEEPEV PAYSIRKGLQ
FGVGDTLTFS CFPGYRLEGT ARITCLGGRR RLWSSPLPRC VAECGNSVTG TQGTLLSPNF
PVNYNNNHEC IYSIQTQPGK GIQLKAKAFE LSEGDVLKVY DGNNNSARLL GVFSRSEMMG
MTLNSTSSSL WLDFITDAEN TSKGFELQFS SFELIKCEDP GTPLFGYKVH DGGHFAGSSV
SFSCDPGYTL RGSEELLCLS GERRTWDRPL PICVAECGGT VKGEVSGQVL SPGYPAPYEH
NLNCIWTIEA DAGCTIGLHF LVFDTEEVHD VLRIWDGPVE SGVLLKELSG PALPKDLHST
FSSVVLQFST DFFTSKQGFA IQFSVSTATS CNDPGVPQNG SRSGSSWEAG DSTVFQCDPG
YALQGSAEIS CVKIENRFFW QPSPPTCIAP CGGDLTGPSG VILSPNYPEP YPPGKECDWK
VTVSPDYVIA LVFNIFNLEP GYDFLHVYDG RDSLSPLIGS FYGSQLPGRI ESSSNSLFLA
FRSDASVSNA GFVIDYTENP RESCFDPGSI KNGTRVGSDL KLGSSITYYC HGGYEVEGSS
TLSCILGPDG KPVWNNPRPV CTAPCGGQYV GADGVVLSPN YPQNYTSGQI CLYFVTVPKD
YVVFGQFTFF HTALNDVVEV HDGHSQQSRL LSSLSGSHTG ESLPLATSNQ VLIKFSAKGQ
APARGFHFVY QAVPRTSATQ CSSVPEPRYG KRLGSDFSVG AVVRFECNSG YALQGSPEIE
CLPVPGALAQ WNVSAPTCVV PCGGNLTERR GTILSPGFPE PYLNSLNCVW KIVVPEGAGI
QIQVISFVTE QNWDSLEVFD GADNTVTMLG SFSGTTVPAL LNSTSNQLYL HFYSDISVSA
AGFHLEYKTV GLSSCPEPAV PSNGVKSGER YLVNDVVSFQ CEPGYALQGH AHISCMPGTV
RRWNYPPPLC IAQCGGAVEE MEGVILSPGF PGNYPSNMDC SWKIALPVGF GAHIQFLNFS
TEPNHDFIEI RNGPYETSRM MGRFSGSELP SSLLSTSHET TVYFHSDHSQ NRPGFKLEYQ
AYELQECPDP EPFANGIVRG AGYNVGQSVT FECLPGYQLI GHPVLTCQHG TNRNWDHPLP
RCEVPCGGNI TSSNGTVYSP GFPSPYSSSQ DCVWLITVFT GHGIRLNLSL LQAETSGDFI
TVWDGPQQTA PQLGVFTRSL VKKTLHSSSN QVLLKFHRNA ATGGIFAIAF SAYPLTKCPP
PTILPNAEVV TENEEFNIGD IVRYRCLSGF TLVGNEILTC KLGTYLQFEG PPPICEVHCP
TNELLTDSTG VILSQSYPGS YPQFQTCSWL VRVEPEYNIS LTVEYFLSEK QYDEFEIFDG
PSGQSPLLKA LSGNYSAPLI VTSSSNSVYL RWSSDHAYNR KGFKIRYSAP YCSLPRTLLH
GFILGQTSTQ PGGSIHFSCN TGYRLVGHSM AICTRHPQGY YLWSEAIPLC QALSCGIPEA
PKNGMVFGKE YTVGTKAVYS CSEGFHLQAG AEATVECLET GLWSNHNIPP QCVAVTCPDI
SSISVEHGRW RLIFETQYQF QAQLMLICDP GYYYTGQRVI RCQANGKWSL GDSLPTCQII
SCGELPIPPN GHRIGTLSDY GATAIFSCNS GYTLVGSRVR ECMANGLWSG SEVRCLAPAK
AGHCGTPEPI VNGHINGENY NYRGSVVYQC NAGFRLIGMS VRICQQDHHW SGKTPFCVPI
TCGHPGNPVN GLTQGNQFNL NDVVKFVCNP GYVADGAARS QCLASGQWSD MLPTCRIINC
TDPGHQENST RQVHASGLHR FSYGTTVLYQ CNHGFYLLGT PVLSCQGDGT WDRPRPQCLL
VSCGHPGSPP HTQMSGDSYT VGAVVRYSCT GKRTLVGNAT RMCGLDGHWT GSLPHCSGTS
MGFCGDPGIP AHGIRLGDSF ASGSLMRFSC EAGHALRGSS ERTCLANGTW SGTQPECGVI
SCGNPGTPSN ARVVFSDSLV FSSSIVYECR EGYYATGLLS RHCSVNGTWT GSDPECIVIN
CGDPGIPANG LRLGNDFRYN KTVTYQCVPG YMMESHRVSV LSCTKDRTWN GTKPVCKAIM
CKPPQLIPNG KVVGSDFMWG SSVIYTCLEG YQLSLPAVLT CEGNGSWTGE LPQCFPVFCG
DPGVPPRGRR EDRGFSYRSS VSYSCQPPLV LVGSPRRFCQ SDGTWSGTQP SCIANPDPTL
TMCADPGVPQ FGIQNNSQGY QVGSTVLFRC QKGYLLQGST TRTCLPNLTW SGTPPDCIPH
HCKQPETPTH ANVGALDLPS MGYTLIYSCQ EGFSLKGGSE HRTCKADGSW TGKPPICLVN
LMLEWHYTVC NSPIPGDVFA KNSLWKGAYE YQGKKQPAML RVTGFQAVSS KVNATMIDHS
GVELHLAGIY KKEDFHLLLQ VYQITGPVEI FVNKFKDDHW ALDGHVSSES SGGTFIYQGS
VKGQDFGQFG FQRLDLRLLE SDPESIGRHF ASNSSSVAAA ILVPFIALII AGFVLYLYKH
RRRPKVPFNG YAGHENTNVR ATFENPMYDR NIQPTDIMAA EAEFTVSTVC TAV
//
