ID   G3UKV8_LOXAF            Unreviewed;       378 AA.
AC   G3UKV8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Forkhead box I1 {ECO:0000313|Ensembl:ENSLAFP00000028467.1};
GN   Name=FOXI1 {ECO:0000313|Ensembl:ENSLAFP00000028467.1};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028467.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000028467.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028467.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000028467.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028467.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   RefSeq; XP_003404697.1; XM_003404649.1.
DR   AlphaFoldDB; G3UKV8; -.
DR   STRING; 9785.ENSLAFP00000028467; -.
DR   Ensembl; ENSLAFT00000029406.1; ENSLAFP00000028467.1; ENSLAFG00000026591.1.
DR   GeneID; 100662536; -.
DR   KEGG; lav:100662536; -.
DR   CTD; 2299; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000161316; -.
DR   HOGENOM; CLU_046860_1_0_1; -.
DR   InParanoid; G3UKV8; -.
DR   OMA; TGIIYHR; -.
DR   OrthoDB; 5385885at2759; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR   CDD; cd20053; FH_FOXI1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF180; FORKHEAD BOX PROTEIN I1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          124..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        124..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  41116 MW;  2EEB8481620140B3 CRC64;
     MSSFDLPAPS SPRCSPQFPS IGQEPPEMNL YYENFFHPQS VPSPQRPPSF EGGGEYGATP
     NPYLWLNGPA MTPPPYLPGT NGSPFLPQAY GMQRPLLPSM AGLGGSDLGW LPLPSQEELM
     KLVRPPYSYS ALIAMAIHGA PDKRLTLSQI YQYVADNFPF YNKSKAGWQN SIRHNLSLND
     CFKKVPRDED DPGKGNYWTL DPNCEKMFDN GNFRRKRKRK SDVSSNTGSL ASEKTENSLL
     AGSPKTMEPQ EVLDSASPGT ASSPEKQSPP PPLGTPCLNN FLSTMTAYVN GSSPVSRSVA
     SPGLSPEPTD KIGQNLLSFN SYTPLTNLNS HGGGGEWANP VPTNALSYGG SVLNQFSPHF
     YNSLNTNSVL YPREGTEV
//