ID G3ULB5_LOXAF Unreviewed; 710 AA.
AC G3ULB5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Interferon-induced GTP-binding protein Mx2 {ECO:0000256|ARBA:ARBA00039835};
DE AltName: Full=Myxovirus resistance protein 2 {ECO:0000256|ARBA:ARBA00042030};
GN Name=MX2 {ECO:0000313|Ensembl:ENSLAFP00000028624.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028624.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028624.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028624.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028624.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028624.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3ULB5; -.
DR Ensembl; ENSLAFT00000028931.1; ENSLAFP00000028624.1; ENSLAFG00000009018.3.
DR GeneTree; ENSGT00940000163266; -.
DR HOGENOM; CLU_008964_8_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF46; INTERFERON-INDUCED GTP-BINDING PROTEIN MX2; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 4: Predicted;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 111..384
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 624..710
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 81278 MW; E29013A1316C039B CRC64;
MPKVHKPCPQ QNQNPLSSQY HPEKEMSSRQ RPPPSFRPAQ KQIMSPPNQQ AGDVTMHFTS
LMLNEQTTSM PPGENRSQPP LGPNMDNQYE EKVRPYIDLI DSLWTLGVEQ DLALPAIVVI
GDQSSGKSSV LEALSGVALP RGSGITTRCP LVLKLKRQPC EYEWRGKLSY RDKELHLHSP
EEVEQVIHKA QNAIAGHGVS ISHELIHLEI TSPEVPDLTL IDLPGIARVA MGNQPQDIGL
QIKSLITKYI KRQETINLVV MPCNVDIATT EALNMAKEVD PDGDRTIGIL TKPDLVDKGL
ETGILNVVRN LTYHLKKGYM IVRCRGQQEI TDKLSLAEAT KREINFFQTH PNFRVLLEEG
RATVPCLAER LTTELIVHIK KSLPLLGQQI QESHQRATEE LRHYGTEVPD KETGKMFFLI
EKVKVFNRDV EKLVEGEEAV KENEIRLYNK IRMEFKTWDH VLAANTEKVK NIVHEEVSKY
ENQYRGKELP GFINYQTFVA IVRQYIQQLV DPALNMLQKV TEIVQQAFIA QAKTNFREFP
NLNQTAQDLI EKIKMRQVEA AENLVQLQFS MEQLVFCQDE LYRAILKEVR ERMSNPLENN
PQLFQRNQLN VFGASVTDPS TSSITEIGVH LNAYFTETSR RLANQIPLII QFFLLQENSD
CLQKSMMHVL QEKEGYGWLL QEQTETAAKR RLLKERIYRL TQARCTLRQF
//