ID G3ULI5_LOXAF Unreviewed; 1040 AA.
AC G3ULI5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Toll like receptor 7 {ECO:0000313|Ensembl:ENSLAFP00000028694.1};
GN Name=TLR7 {ECO:0000313|Ensembl:ENSLAFP00000028694.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028694.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028694.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028694.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028694.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028694.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; G3ULI5; -.
DR STRING; 9785.ENSLAFP00000028694; -.
DR Ensembl; ENSLAFT00000001156.3; ENSLAFP00000028694.1; ENSLAFG00000001156.3.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000159771; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR InParanoid; G3ULI5; -.
DR OMA; CNSKYLR; -.
DR TreeFam; TF325595; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0032009; C:early phagosome; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0070305; P:response to cGMP; IEA:Ensembl.
DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1040
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003456397"
FT TRANSMEM 831..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 880..1024
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1040 AA; 119482 MW; 255A2FF7BE60E836 CRC64;
QVFWMRTLNR LFLILLNVVL ISKPLGAIWF PKTLPCEVTV DVPKAHVIVD CTDKHLMEIP
GGIPTNATNL TLTINHIPAI SPASFRRLEH LVEIDFRCNC VPIRLGPKDN ICTRGLQIKP
KSFSRLTSLK ALYLDGNQLL EIPQGLPAGL KLLSLEANTI FSIMKENLTE LANIEILYLG
QNCYYRNPCN VSFSIEKDAF LSLKNLKVLS LKDNNITAVP TVLPSTLTEL YLYNNIITKI
EEHDFNNLNQ LQHLDLSGNC PRCYNVPFPC TPCENNSPLQ IHVNAFDALL ELRVLRLHSN
SLQHVPKRLF QNIKKLEELD LSQNFLAKEI GDAKFLHFLP NLVQLDLSFN YELQVYHAHM
NLSNEFSSLR NLRVLRIKGY VFKELKSLNL FPLQSLPYLE VLDLGTNFIK VADLSIFKQF
ERLKFIDLSM NKISPSGDSS DVGFCPNSRT SVDSYGPQVL ETGHYFRYDD YARSCRFKYK
ETPVLPFNEN CNMYGQTLDL SSDFQHLSFL KCLNLSGNSI SQTLNGSELQ PLVELKYLDF
SNNRLDLLHS TAFEGLRNLE VLDISSNGHY FQSEGLTHML NFTKNLNVLK KLMMNNNGIS
TSSSRTMESN SLKTLEFRGN YLNVFWKDGD NRYLQFFKNL QNLEELDISE NSLSFLPPGV
FDGMPPNLKT LSLAKNGLKS FNWGRLEVLK NLETLDLSNN QLKTVPERLA NCSSSLKKLI
LKNNQIRRLT KYFLQGAFQL RYLDLSSNKI QIIQKTSFPE NVLNNLELLL LHHNRFLCTC
DAVWFVWWVN HTEVTIPYLA TDVTCVGPGA HRGQSVVSLD LYTCELDLTN LILYSFSISI
ALFLMVVTTA SHLYFWDVWY SYYFCKAKIK GYRRLISPDS CYDAFIVYDT KDPAVTEWVL
DELVAKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL SKKTVFVMTD KYAKTENFKI
AFYLSHQRLI DEKVDVIILI FLEKPLQKSK FLQLRKRLCG SSVLEWPTNP QAHPYFWQCL
KNALATDNHV AYSQVFKETV
//
