ID G3UNP0_LOXAF Unreviewed; 491 AA.
AC G3UNP0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO3A1 {ECO:0000313|Ensembl:ENSLAFP00000029449.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000029449.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000029449.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000029449.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000029449.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000029449.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR AlphaFoldDB; G3UNP0; -.
DR STRING; 9785.ENSLAFP00000029449; -.
DR Ensembl; ENSLAFT00000033091.1; ENSLAFP00000029449.1; ENSLAFG00000013948.3.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01080000257410; -.
DR HOGENOM; CLU_008954_3_0_1; -.
DR InParanoid; G3UNP0; -.
DR OMA; NINCECQ; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015132; F:prostaglandin transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF86; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 3A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 135..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 355..378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 406..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 246..294
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 491 AA; 53444 MW; FC2256ED29A33186 CRC64;
GILFTMLVFG PACGFILGSF CTKIYVDAVF IDTSNLDITP DDPRWIGAWW GGFLLCGALL
FFSSLLMFGF PQSLPPHSDP AMESEQAMLP EREYERPKPS NGVLRHPLEP DSSASCFQQL
RVIPKVTKHL LSNPVFTCII LAACMEIAVV AGFAAFLGKY LEQQFNLTTS SANQLLGESI
TPSSRGQGKA VVYVICKNLL RASKESAPCW ACSSSIYLVF LSATCSPGPV LQGTAYRALS
VAGSALDPYS PCNNNCECQT DSFTPVCGAD GITYLSACFA GCNSTNLTGC ACLTTVPPEN
ATVVPGKCPS PGCQEAFLTF LCVMCACSMI GAMAQTPSVI ILIRTVSPEL KSYALGVLFL
LLRLLGFIPP PLIFGAGIDS TCLFWSTFCG EQGACVLYDN VIYRYLYVSI AIALKSFAFI
LYTTTWQCLR KNYKRYIKNH EGGLSTSEFF ASTLTLDNLG RDPVPANQTH RTKFIYNLED
HEWCENMESV L
//
