ID G3UNP5_LOXAF Unreviewed; 3045 AA.
AC G3UNP5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cadherin related 23 {ECO:0000313|Ensembl:ENSLAFP00000029454.1};
GN Name=CDH23 {ECO:0000313|Ensembl:ENSLAFP00000029454.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000029454.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000029454.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000029454.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000029454.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000029454.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000029454; -.
DR Ensembl; ENSLAFT00000027476.1; ENSLAFP00000029454.1; ENSLAFG00000015162.3.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000155245; -.
DR HOGENOM; CLU_000457_0_0_1; -.
DR InParanoid; G3UNP5; -.
DR OMA; ITRPSHH; -.
DR TreeFam; TF316403; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0098683; C:cochlear hair cell ribbon synapse; IEA:Ensembl.
DR GO; GO:0060091; C:kinocilium; IEA:Ensembl.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR GO; GO:0098684; C:photoreceptor ribbon synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0090102; P:cochlea development; IEA:Ensembl.
DR GO; GO:0050957; P:equilibrioception; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0050953; P:sensory perception of light stimulus; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 24.
DR Gene3D; 2.60.40.60; Cadherins; 24.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 22.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 24.
DR SUPFAM; SSF49313; Cadherin-like; 24.
DR PROSITE; PS00232; CADHERIN_1; 11.
DR PROSITE; PS50268; CADHERIN_2; 24.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2758..2781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..147
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 148..248
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 249..358
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..472
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 467..578
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 579..683
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 684..790
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 791..896
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 898..1001
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1002..1106
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1108..1216
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1218..1323
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1324..1433
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1448..1542
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1543..1650
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1651..1760
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1761..1865
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1866..1984
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1988..2093
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2094..2200
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2201..2302
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2305..2413
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2420..2537
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2538..2658
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 3045 AA; 335541 MW; F492D5BF3B27727E CRC64;
LHLQGTELND DRTPSDATVT TTFNILVIDI NDNAPEFNSS EYSVAITELA QVGFALPLFI
QVVDKDEGLN SMFEVFLVGN NSHHFIISPT SVQGKADIRI RVAIPLDYET VDRYDFDLFA
NESVPDHVGY AKVKITLINE NDNRPIFSQP LYNVSLFENA TVGTSVLTVL AVDADVGGAG
EVIYFFKDGE ARFSLDKDMG LIMLIAKLDY ELIQRFTLTV IARDGGGEET TGRVRINVLD
VNDNMPTFQK DAYVGALREN EPSVTQLVRL RATDEDSPPN NQITYSVVDA SAFGSYFDIS
TYEGYGVISV SRPLDYEQIP NGLIYLTVMA RDAGNPPLNS TVPVTIEVFD ENDNPPTFSK
PAYFVSVVEN IMAEGATVLF LNATDLDRSR EYGQESIIYS LEGSSQFRIN ARSGEITTTS
LLDREMKAEY ILIVRAVDGG VAHNQKTGIV TVNITLLDIN DNHPTWKDAP YYINLVEMTP
PDSDVTTVVA VDPDLGENGT LVYSIQPPNK FYSLNSTTGK IRTTHVMLDR ENPDPQEAEF
MRKIIVSVTD RGRPPLRATS SATVFVNLLD LNDNDPTFQN LPFMAEVLEG TPAGVSVYQV
VAVDLDEGLN GLVSYRMQVG MPRMDFLINS SSGVVVTTAE LDRERIAEYQ LRVVASDAGT
PTKSSTSTLT IRVLDVNDET PTFFPALYNV SVSEDVPRDF RVVWLNCTDN DMGLNAELSY
FITGGNVDGK FSVGYRDAVV RTVVSLDRET TAAYTLILEA IDNGPVGKRR TGTTTVFVTV
LDVNDNRPIF LQSSYEASVP EDIPEGHSIV QLKATDADEG EFGLVWYRIL HGNHGNNFRI
HVSNGLLMRG PRPLDREQNS SHVLVVEAYN HDLGPMRSSI RVIVYVEDVN DEAPVFTQQQ
YSRLGLRETA GIGTSVIVVR AMDRDTGDGG LVNYRILSGA EGKFEIDEGT GLIITVDYLD
YETKTSYLIN VSATDQAPPF NQGFCSVYIT LLNELDEAVQ FSNASYEAAI MENLALGTEI
ARIQAYSIDN LNQITYRFDT YTSAQAKALF KIDAITGVIT VKGLVDREKG DLYTLTVVAD
DGGPKADSTV KVYITVLDEN DNSPQFDFTS DLAVSVPEDC SVGQRVATVK AQDPDAGSNG
QQVVFSLASG NIAGTFEIAT TNDSIGEVFV ARPLDREELD HYFLKIMASD LGTPPRKKDH
ILQVTILDIN DNPPVIESPF GYNVSVNENV GGGTAVVQVR ATDRDIGLNS ILSYYITEGN
EDMTFRIDRI SGEITTRPAP PDREHKSFYH LVVTVEDEGT PTLSATTHVY VTIVDENDNA
PVFQRPHYEV LLDEGPDTIN ASLVTIQALD LDEGPNGTVT YAIVSGNIIN TFRINRRMGV
ISATKELDYE ISHGCYTLIV TATDQCPILS HRLTSTTTVL VNVNDINDNA PTFPRDYEGP
FDVTEGQPGP RVWTFLAHDR DSGPNGQVEY SIMDGDPLDP GEFLISPVEG VLRVRKDVEL
DRETIAFYNL TICARDRGVP PLSSTMLVGI RVLDINDNDP LLLNLPMNIT ISENTPVSSF
VAHILASDAD SGCNALLTFN ITAGNRERAF FINATTGIIT VNQPLDRERI PEYKLTISVK
DNPENPRIAR RDFDFLLIFL ADENDNHPLF TESTYQAEVM ENSPTGTPIT VLNGPILALD
ADQDVYAVVT YQLLGAQSDL FDINNSTGMV TVRSGVIIDR EAFSPPVLEL LLLAEDIGLL
NGTADLLIAI LDDNDNWPTF SPNALTVHLL ENCPPGFSVL QVTATDEDSG LNGELVYRIE
AGAQDRFLIH PVTGVIRVSN VTIDREEQES YRLTVVATDR GTVPLSGTAI ISVLIEDIND
SRPEFLNPIQ TVSVLESAEP GTVIANVTAI DRDLNPKLEY HIIGIVAKDD TDHLVPNQED
AFAVNINTGS VIVKSPLNRE LVATYEVTLS VIDNASDLPE HAVSVPNAKL TVNILDVNDN
TPKFKPFGIT YYTERVLEGA TPGTTLIAVA AVDPDKGLNG LITYTLLDLV PPGYVQLEDS
SMGKVIANRT VDYEEVHWFN FTVRASDNGS PPRAAEIPVY LEIVDINDNN PIFDHPSYQE
AIFEDVPVGT VILTVSATDT DSGNFARIEY SLVDGEGKFA INPTTGDIYV LSSLDREKKD
HYILTALAKD NPGDVASNRR ENSVQVVIQV LDVNDCRPQF SKTQFSTSVY ENEPAGTSVI
TMVATDQDEG PNAELAYSLE GPGAEAFHVD MDSGLVTTKR PLQSYERFNL TVVATDGGDP
PLWGTTMLLV EVIDVNDNRP VFVRPPNGTI LHIREEIPLR SNVYEVYATD KDEGLNGAVR
YSFLKTAGNR DWEYFTIDPI SGLIQTAQRL DRETQAVYSL ILVASDLGQP VPYETMQPLQ
VALEDIDDNE PLFARPPKGS PQYQLLTVPE HSPRGTLVGN VTGAVDADEG SNAIVYYFIA
AGNKEKNFHL QPDGCLLVLR DLDREREAVF SIIVKASSNR SWTPPHEPSL ALDLLADPTL
QEVRVVLEDI NDQPPRFTKA EYTAGVATDA KVGSELVQVL ALDADIGNNS LVFYSILAIH
YFRALANDSE DVGQVFTMGS VDGILRTFDL FTAYSPGYFV VDIVARDLAG HSDTAIIGIY
ILRDDQRVKI VINEIPERVR GFKEEFTRLL ANITGAIVNT DDVQFHVDKK GRVNFAQTEL
LIHVVNRDTN RILDVDRVIQ MIDENKEQLR NLFRNYNVLD VQPAISVRLP DDMSALQMAI
IVLAILLFLA AMLFILMNWY YRTIHKRKLK AIVAGSAGNR GFIDIMDMPN TNKYSFDGAN
PVWLDPFCRN LELAAQAEHE DDLPENLSEI ADLWNSPTRT HGTFGREPAA VKPDDDRYLR
AAIQEYDNIA KLGQVIREGP IKGSLLKVVL EDYLRLKKLF AQRMVQKASS CHSSISELIQ
TELEEEPGER SPGQGSLRFR HKPPMEFKGP DGIHVVHGST GTLLATDLNS LPEDDQKGLG
RSLETLTAAE ASAYERNART ESAKSTPLHK LRDVIMESPL EITEL
//
